Effect of iodinated low-osmolar contrast media on the hemostatic system after intraarterial and intravenous contrast administration |
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| Authors: | A Lukasiewicz U Lebkowska M Galar |
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| Institution: | 1. Department of Radiology, Medical University of Bialystok, Bialystok, Poland;2. Department of Hematology, Medical University of Bialystok, Bialystok, Poland;1. Department of Dental Propaedeutics, Medical University of Bialystok, Bialystok, Poland;2. Department of Conservative Dentistry, Medical University of Bialystok, Bialystok, Poland;3. Department of Periodontal and Oral Mucosal Diseases, Medical University of Bialystok, Bialystok, Poland;4. Department of Biotechnology, Medical University of Bialystok, Bialystok, Poland;1. University Claude Bernard Lyon, Faculty of Pharmacy, Laboratory of Pharmacology, INSERM team on vascular attacks and tissue responses, Lyon, France;1. Department of Physiology 2, Kawasaki Medical School, Kurashiki, Japan;2. Department of Rehabilitation, Kawasaki University of Medical Welfare, Kurashiki, Japan;3. Department of Physiology 1, Kawasaki Medical School, Kurashiki, Japan;1. Department of Otolaryngology, Wroclaw Medical University, Wroclaw, Poland;2. Department of Molecular Biology and Medical Genetics, Medical University of Silesia, Sosnowiec, Poland;3. Clinical Department of Internal Diseases, Dermatology and Allergy, Medical University of Silesia, Zabrze, Poland |
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| Abstract: | PurposeSome of the adverse clinical effects of intravascular radiological contrast agents include the interference of these contrast media with normal hemostatic processes. The aim of this report was to investigate in vivo whether a non-ionic iodinated contrast agent possess prothrombotic or anticoagulant properties.Material and methodsHemostatic parameters: vWF (von Willebrand factor), F1+2 (prothrombin fragments 1+2), TAT (thrombin-antithrombin complexes), D-Dimer, β-TG (beta-thromboglobulin) were measured in a group of 35 patients. Blood samples for laboratory investigations were collected before and 30 min after the administration of a iodine contrast agent.ResultsThere was observed statistically highly significant contrast-induced increase in TAT and F1+2 (p = 0.005 and p = 0.008, respectively). D-Dimer increase and decrease of β-TG and vWF after contrast medium administration were non significant. The volume of contrast medium has no influence on the assessed hemostatic parameters, while the type of contrast medium and/or the route of the contrast administration may significantly affect hemostatic parameters.ConclusionWe found significant effects of non-ionic agents on hemostatic activation. These effects may be important for adverse reactions and for thromboembolic complications. |
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