| RNA m6A修饰与心血管疾病研究进展 |
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| 引用本文： | 宁小彤,任晓晓,王来元,陈恕凤.RNA m6A修饰与心血管疾病研究进展[J].中国分子心脏病学杂志,2021(1):3784-3788. |
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| 作者姓名： | 宁小彤 任晓晓 王来元 陈恕凤 |
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| 作者单位： | 中国医学科学院北京协和医学院阜外医院中国医学科学院心血管流行病学重点实验室流行病学研究部 |
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| 基金项目： | 中国医学科学院医学与健康科技创新工程(2016-I2M-2-001)。 |
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| 摘 要： | 心血管疾病已成为我国成年人群的首位死亡原因。但其病因多样,发生机制至今仍未完全阐明。大量研究表明表观遗传修饰在心血管疾病发生发展中起重要作用。N6-甲基腺苷(m6)修饰是RNA最普遍的一种表观遗传修饰。研究提示m6修饰可能在心血管疾病中发挥重要功能。本文就RNA m6修饰在心血管疾病中的调控作用的相关研究进行综述。
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| 关 键 词： | RNA修饰 N6-甲基腺苷 表观遗传 心血管疾病 |
Advances on the Roles of RNA m6A Modification in Cardiovascular Disease |
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| NING Xiao-tong,REN Xiao-xiao,WANG Lai-yuan,CHEN Shu-feng.Advances on the Roles of RNA m6A Modification in Cardiovascular Disease[J].Molecular Cardiology of China,2021(1):3784-3788. |
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| Authors: | NING Xiao-tong REN Xiao-xiao WANG Lai-yuan CHEN Shu-feng |
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| Institution: | (Key Laboratory of Cardiovascular Epidemiology&Department of Epidemiology,Fuwai Hospital,National Center for Cardiovascular Diseases,Chinese Academy of Medical Sciences,Peking Union Medical College,Beijing 100037,China) |
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| Abstract: | Cardiovascular disease(CVD)has become the leading cause of death in the adult population in China.Its etiology is various and the pathogenesis has not been fully elucidated so far.A number of studies have shown that epigenetic modifications play critical roles in the occurrence and development of CVD.N6-methyladenosine(m6)is the most common epigenetic modification in RNA.Studies suggested that m6modification may play a primary role in CVD.In this review,we summarized recent advances on the role of RNA m6modification in CVD. |
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| Keywords: | RNA modification N6-methyladenosine Epigenetics Cardiovascular disease |
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