多囊卵巢综合征患者血清中Neudesin水平及其与多项生理生化指标的相关性分析

目的　探究多囊卵巢综合征(polycystic ovarian syndrome, PCOS)患者血清中Neudesin的水平及其与多项生理生化指标的相关性分析。方法　选取2018年9月至2019年10月安康市人民医院收治的53例PCOS患者为观察组,另选取同期50例体检健康女性为对照组。通过酶联免疫吸附测定法(ELISA)检测血清中Neudesin水平,电化学发光免疫分析法(ECLIA)检测血清卵泡刺激素(follicle-stimulating hormone, FSH)水平。结果　两组超敏C反应蛋白(high-sensitivity C-reactive protein, hs-CRP)和Neudesin水平比较差异具有统计学意义（t=11.63,12.69,均P＜0.001）,并且观察组的hs-CRP水平高于对照组（1.33±0.42mg/L vs 0.50±0.21mg/L）,而观察组的Neudesin水平低于对照组(4.13±1.65ng/ml vs 6.83±2.19ng/ml)。Spearson相关性检验显示Neudesin与平均年龄、空腹血糖(fasting blood-glucose, FBG)、总胆固醇(total cholesterol, TC)、低密度脂蛋白胆固醇(low density lipoprotein cholesterin, LDL-C)、hs-CRP和FSH无显著相关性,而与身体质量指数(body mass index, BMI)呈显著负相关关系(r=-0.24,P=0.01)。结论　PCOS患者血清中Neudesin水平较低并且其受BMI的影响。

Correlation Analysis of Serum Neudesin Level and Multiple Physiological and Biochemical Indexes in Patients with Polycystic Ovarian Syndrome

Objective To investigate the correlation analysis of serum Neudesin level and multiple physiological and biochemical indexes in patients with polycystic ovarian syndrome(PCOS).Methods Fifty-three PCOS patients admitted to Ankang People’s Hospital from September 2018 to October 2019 were selected as the observation group,and 50 healthy women in the same period were selected as the control group.Serum Neudesin levels were detected by enzyme-linked immunosorbent assay(ELISA),the electrochemical luminescence immunoassay(ECLIA)detected the levels of serum follicle-stimulating hormone(FSH).Results The difference in the levels of high-sensitivity C-reactive protein(hs-CRP)and Neudesin between the two groups was statistically significant(t=11.63,12.69,all P<0.001).Moreover,the hs-CRP level of the observation group was higher than that of the control group(1.33±0.42mg/L vs 0.50±0.21mg/L),while the Neudesin level of the observation group was lower than that of the control group(4.13±1.65ng/ml vs 6.83±2.19ng/ml,P<0.001).Spearson correlation test showed that there were no significant correlation between Neudesin level and average age,fasting blood glucose(FBG),total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C),hs-CRP and FSH,and Body Mass Index(BMI)showed a significant negative correlation(r=-0.24,P=0.01).Conclusion Serum Neudesin levels were lower in PCOS patients and were affected by BMI.