Hypoglycemic effect of Costus pictus D. Don on alloxan induced type 2 diabetes mellitus in albino rats |
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| Authors: | S Suganya R Narmadha VK Gopalakrishnan K Devaki |
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| Institution: | 1. Laser Research Centre, Faculty of Health Sciences, University of Johannesburg, Doornfontein, 2028, Johannesburg, South Africa;2. Bioprospecting laboratory, Department of Botany, Bharathiar University, Coimbatore, Tamil Nadu, 641046, India;1. Department of Biochemistry, Sam Higginbottom Institute of Agriculture, Technology & Sciences, Allahabad 211008, U.P, India;2. Jacob School of Biotechnology & Bioengineering, Sam Higginbottom Institute of Agriculture, Technology & Sciences, Allahabad 211008, U.P, India;3. Department of Biological Science, Rani Durgavati University, Jabalpur 482001, MP, India;1. Endocrine Physiology Research Center, Research institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran;2. Neurophysiology Research Center and Department of Physiology, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran;3. Department of Molecular, Cellular and Biomedical Sciences, Sophie Davis School of Biomedical Education, City University of New York School of Medicine, New York, USA;1. Centre for Advanced Studies in Botany, University of Madras, Chennai, India;2. Department of Virology, King Institute of Preventive Medicine & Research, Chennai, India;1. Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, 143005, India;2. Department of Botanical and Environmental Sciences, Guru Nanak Dev University, Amritsar, 143005, India;3. Sri Guru Ram Das Institute of Medical Sciences and Research, Amritsar, 143005, India;4. Department of Pathology and Laboratory Medicine, University of Ottawa, Faculty of Medicine, Ottawa, Ontario, Canada |
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| Abstract: | ObjectiveTo demonstrate the effect of aqueous extract of Costus pictus (C. pictus) leaves on blood glucose, lipid profile and liver antioxidant enzymes and lipid peroxidation in alloxan induced diabetic rats.MethodsAqueous extract of C. pictus (AECP) leaves was administered orally for 30 days and its effect on blood glucose, lipid profile, hepatic marker enzymes such as serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), serum urea, creatinine, protein and albumin content and liver antioxidant enzymes such as catalase, peroxidase, superoxide dismutase and lipid peroxidation in alloxan induced diabetic rats were examined.ResultsOral administration of aqueous extract of C. pictus leaves to diabetic rats for 30 days significantly reduced the levels of blood glucose, lipid profile, lipid peroxidation, liver marker enzymes, urea, creatinine and increased the levels of antioxidant enzymes.ConclusionsThe aqueous extract of C. pictus leaves controls the blood glucose level, improves lipid metabolism and prevents diabetic complications associated with lipid peroxidation and also maintains the antioxidant enzymes in experimental diabetic rats. Therefore, it can be recommeded for the prevention of diabetes mellitus. |
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