Assessment of brain oxygenation in term and preterm neonates using near infrared spectroscopy |
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| Authors: | R Bokiniec A Zbiec J Seliga P Sawosz A Liebert I Klosinska A Bargiel R Maniewski MK Kornacka |
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| Institution: | 1. Neonatal and Intensive Care Department, Warsaw Medical University, Warsaw, Poland;2. Department for Biophysical Measurements and Imaging, Na??cz Institute of Biocybernetics and Biomedical Engineering PAS, Warsaw, Poland;1. Department of Reproduction and Gynecological Endocrinology, Medical University of Bialystok, Poland;2. Department of Biology and Pathology of Human Reproduction in Bialystok, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Olsztyn, Poland;3. Genetics, Caen University Hospital-F 14033 Caen, France;4. Estrogen and Reproduction – Team 2608 – Institut Fédératif de Recherche ICORE - University of Caen- F 14032 Caen, France;1. Department of Otolaryngology, Wroclaw Medical University, Wroclaw, Poland;2. Department of Molecular Biology and Medical Genetics, Medical University of Silesia, Sosnowiec, Poland;3. Clinical Department of Internal Diseases, Dermatology and Allergy, Medical University of Silesia, Zabrze, Poland;1. Department of Radiology, Medical University of Bialystok, Bialystok, Poland;2. Department of Hematology, Medical University of Bialystok, Bialystok, Poland;1. Department of Immunopathology of Infectious and Parasitic Diseases, Medical University of Warsaw, Poland;2. Hospital of Infectious Diseases, Warsaw, Poland;3. Clinical Department of Infectious Diseases, Medical University of Warsaw, Poland |
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| Abstract: | PurposeThe aim of this study was to determine brain oxygenation in full-term and preterm neonates using near infrared spectroscopy.Material and methodsA total of 88 full-term and preterm newborn infants without hypoxic-ischaemic disorders admitted to the NICU were examined using NIRS on the first day of life and on day 28 of life. Additional measurements were taken at the end of the first week of life in the premature neonates group. Measurements of oxyhaemoglobin (HbO2), deoxyhaemoglobin (Hb), total haemoglobin (HbT) concentration and tissue oxygen saturation (Ox) were performed in 5 brain regions. Right and left frontal areas, the occipital area and right and left temporal areas were measured.ResultsIn full-term healthy neonates a marked decrease in HbO, Hb and HbT values was observed on day 28 of life in all brain regions except the occipital area. In the neonatal period the greatest changes in brain oxygenation occurred in the right and left frontal regions of the brain. In preterm neonates constant values of HbO2 and Ox were observed in the first 28 days of life. In preterm newborn infants, as well as in full term newborn infants, similar Ox and HbO2 values were obtained on day 28 of life.ConclusionsNIRS is a safe method and can be used to evaluate brain oxygenation in newborn infants. The results of these measurements are in accordance with changes in brain oxygenation in the first month of life, which are predicated on the basis of the neonate's physiology. |
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