慢性阻塞性肺疾病患者血清IL-6、hs-CRP水平与肺功能指标的关系 |
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引用本文: | 夏珊,;张紫燕. 慢性阻塞性肺疾病患者血清IL-6、hs-CRP水平与肺功能指标的关系[J]. 海南医学院学报, 2014, 0(10): 1349-1350 |
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作者姓名: | 夏珊, 张紫燕 |
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作者单位: | [1]重庆市合川区人民医院呼吸科,重庆合川区401520; [2]深圳市龙华新区人民医院健康服务中心,广东深圳518000 |
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基金项目: | 深圳市宝安区科技项目(2010655). |
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摘 要: | 目的:探讨慢性阻塞性肺疾病(COPD)患者血清白介素6(IL-6)、超敏C反应蛋白(hs-CRP)与肺功能的关系。方法:选择50例COPD患者作为研究对象,其中COPD急性加重期患者30例纳入AECOPD组,COPD稳定期患者20例纳入SCOPD组,选取25例健康者纳入对照组,比较3组血清hsCRP、IL-6水平,以及SCOPD、AECOPD患者hs-CRP、IL-6水平与肺功能指标的相关性。结果:AECOPD组患者hs-CRP、IL-6水平高于SCOPD组和对照组,SCOPD组患者hs-CRP、IL-6水平高于对照组,差异有统计学意义(P〈0.05);SCOPD组、AECOPD组患者血清hs-CRP、IL-6与第一秒用力呼气量占预计值百分比(FEV1%)、FEV1/用力肺活量(FVC)均呈负相关(P〈0.05)。结论:血清hs-CRP、IL-6参与了COPD的炎症反应,并且与COPD患者的肺功能损伤有关。
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关 键 词: | 慢性阻塞性肺疾病(COPD) 白介素6(IL-6) 超敏C反应蛋白(hs-CRP) 肺功能 |
Relationship between levels of serum high-sensitive C-reactive protein,interleukin 6 and lung function in patients with chronic obstructive pulmonary disease |
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Affiliation: | XIA Shan , ZHANG Zi-yan (1. 3rd People's Hospital of Chongqing City, Chongqing 401520, China;2. Community Health Centre ,Peoplds Hospital of Longhua District, Shenzhen 518000, China) |
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Abstract: | Objective:To investigate the relationship between levels of serum high-sensitive C-reactive protein(hsCRP),interleukin 6(IL-6)and lung function in patients with chronic obstructive pulmonary disease(COPD).Methods:A total of 50 patients with COPD were divided into acute exacerbation of COPD(AECOPD)group(n=30),and stable COPD(SCOPD)group(n=20),and 25 healthy people as the control group.Serum hs-CRP,IL-6levels were compared,and correlation between levels of hs-CRP,IL-6and lung function indicators in COPD were analyzed.Results:The hs-CRP,IL-6levels in AECOPD patients were significantly higher than the SCOPD group and the control group,and that in SCOPD group were significantly higher than the control group(P〈0.05).The serum hs-CRP,IL-6in SCOPD and AECOPD was negatively correlated with FEV1%,FEV1/FVC(P〈0.05).Conclusion:The serum hs-CRP,IL-6involve in the inflammatory response in COPD and lung function injuries in patients with COPD. |
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Keywords: | Chronic obstructive pulmonary disease IL-6 High-sensitive C-reactive protein Lung function |
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