| 桑蒂复肝胶囊对D-半乳糖胺致小鼠急性肝损伤的保护作用 |
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| 引用本文： | 李莉,;张喜德,;张恩户.桑蒂复肝胶囊对D-半乳糖胺致小鼠急性肝损伤的保护作用[J].河北中医学院学报,2014(3):9-11. |
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| 作者姓名： | 李莉 ;张喜德 ;张恩户 |
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| 作者单位： | [1]河南省平顶山学院医学院,平顶山467000; [2]陕西中医学院,咸阳712046 |
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| 基金项目： | 陕西省科技厅课题基金资助项目：No 03 K10-G14 |
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| 摘 要： | 目的：研究桑蒂复肝胶囊对D-半乳糖胺（D-GlaN）致小鼠急性肝损伤的保护作用。方法：采用腹腔注射D-GlaN建立小鼠急性肝损伤模型，观察桑蒂复肝胶囊对小鼠血清丙氨酸氨基转移酶（ ALT）、天门冬氨酸氨基转移酶（ AST）水平，肝组织匀浆超氧化物歧化酶（ SOD）活力、脂质过氧化物丙二醛（ MDA）含量和肝组织病理学检查的影响。结果：与模型组对比，桑蒂复肝胶囊高、中剂量组能够显著降低小鼠血清ALT、 AST水平，提高肝组织匀浆SOD活力，降低MDA含量，改善肝组织病理损伤程度（ P ＜0.05或P ＜0.01）。结论：桑蒂复肝胶囊对D-GlaN致小鼠急性肝损伤有明显的保护作用。
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| 关 键 词： | 桑蒂复肝胶囊 D-半乳糖胺 肝损伤 保护作用 肝炎 乙肝解毒胶囊 |
Protection of Sangdi Fugan Capsule on Mice with D-GlaN-induced Acute Liver Injury |
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| Institution: | LI Li, ZHANG Xi-de, ZHANG En-hu(Medical School of Pingdingshan College, Henan Province( Pingdingshan 467000)) |
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| Abstract: | Objective：to explore the protective effect of Sangdi Fugan Capsule on the mice with D-GlaN-induced acute liver injury.Methods：Mice models with acute liver injury were made by intraperitoneal injection of D -GlaN.Observe the effect of the capsule on ALT, AST in serum, SOD activity in liver sissue homogenate , MDA content and liver histopathology.Results：Compared to model group, Sangdi Fugan Capsule of high and low dosage groups could significantly decrease ALT and AST content , increase SOD activity, decrease MDA content, improve the injury of liver tissue （ P 〈0.05 or P 〈0.01） .Conclusion：Sangdi Fugan Capsule hasan apparent protective effect on the mice with D-GlaN-induced acute liver injury. |
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| Keywords: | Sangdi Fugan Capsule D-GlaN liver injury protective effect hepatitis Hepatitis-B Detoxication Capsule |
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