苯丙胺类兴奋剂、氯胺酮及其混合滥用所致精神障碍的临床精神症状的比较分析简

目的獉獉：比较分析苯丙胺类中枢兴奋剂、氯胺酮及其混合滥用所致精神障碍的住院患者临床精神症状的差异。方法獉獉：对2010年1月-2011年12月华中科技大学同济医学院附属精神卫生中心成瘾病房收治的苯丙胺类兴奋剂、氯胺酮、及其混合滥用所致的精神障碍375例患者的病例资料进行回顾性分析,分组别对患者入院时简明精神病评定量表评定数据进行统计学分析。结果獉獉：（1）苯丙胺类兴奋剂滥用组和苯丙胺类兴奋剂＋氯胺酮混合滥用组在简明精神病评定量表总分差异没有统计学意义（P〉0.05）,但他们都显著高于氯胺酮滥用组（P〈0.001）。3组5个因子分的两两比较差异均有显著意义（P〈0.01）。（2）苯丙胺类兴奋剂滥用组的思维障碍因子分、激活性因子分和敌对性因子分显著高于氯胺酮滥用组,而焦虑抑郁因子分、活力缺乏因子分显著低于氯胺酮滥用组,苯丙胺类兴奋剂＋氯胺酮混合滥用组则介于两者之间。（3）苯丙胺类兴奋剂滥用组和氯胺酮滥用组尿检阳性的患者简明精神病评定量表因子分和总分均显著高于尿检阴性的患者（P〈0.01）。结论獉獉：苯丙胺类兴奋剂、氯胺酮以及两种混合滥用所致精神障碍的精神症状存在明显差异,需要根据他们的临床特征制定相适宜的治疗措施。

COMPARISON OF PSYCHIATRIC SYMPTOMS AMONG INPATIENTS WHO USED AMPHETAMINE TAPE STIMULANTS,KETAMINE OR MIXED OF THEM

Objectve：To compare the differences of psychiatric symptoms among inpatients who used amphetamine type stimulants （ ATS）, ketamine （ K）, or mixes/mix of them. Methods ： A retrospective analysis was conducted in 375 inpatients from the drug abuse treatment ward, Wuhan mental health center, between January 2010 and December 2011. The patients were diagnosed with mental disorders due to abusing ATS - only, ketamine - only, or both. The Brief Psychiatric Rating Scale （BPRS） was used to evaluate the symptoms of the patients. Results ： （ 1 ） There was no difference between the patients from ATS -only group and ATS ＋ K group for BPRS total scores （P 〉0.05）. However, the scores of these two groups were significantly higher than those from ketamine -only group （P 〈0.001 ）. There was significant difference from each other in five factors scores for three groups （P 〈0.01, respectively）. （2） Patients in ATS - only group had lower scores than ketamine - only group in anxiety - depression factor and anergia factor. And ATS patients had higher scores in thinking - disorder factor, activity factor and hostility factor comparing with the ketamine -only group. Patients in ATS ＋ K group had middle scores among three groups. （3） Considering the patients from ATS -only and ketamine -only groups, patients whose urinary tests were positive had higher BPRC scores in total score and all factors fields than the person with negative urinary tests（ P 〈 0.01 ）. Conclusion ： The patients who abused ATS - only, ketamine - only, or both of them showed different psychiatric symptoms. The relevant services are recommended to engage these individuals in the treatment process.