食管癌患者化疗对机体抗氧化作用及免疫功能的影响

目的：研究食管癌患者化疗对脂质过氧化反应、抗氧化作用及免疫功能的影响。方法：选取食管癌化疗患者79例作为研究资料,对照研究所有患者化疗前后的免疫功能、脂质过氧化反应以及抗氧化作用各指标,并分析其相关性。结果：患者化疗后的丙二醛（MDA）、可溶性白介素-2受体（aIL-2R）水平显著高于治疗前（P〈0.05）,谷胱甘肽过氧化物酶（GSH-Px）和白介素-6（IL-6）水平显著低于治疗前（P〈0.05）,超氧化物歧化酶（T-SOD）化疗前后无显著差异（P〉0.05）。化疗前aIL-2R水平与T-SOD和MDA无显著相关性,与GSH-Px存在负相关性;化疗前IL-6水平与MDA存在负相关性,与T-SOD存在正相关性,与GSH-Px无显著相关性。而aIL-2R的化疗前后差值与GSH-Px差值存在负相关性,与MDA差值存在正相关性,与T-SOD差值无显著差异相关性;IL-6的化疗前后差值与T-SOD差值存在正相关性,与MDA差值和GHS-Px差值无显著相关性。结论：食管癌患者化疗对脂质过氧化反应和抗氧化作用影响显著,从而对患者的免疫功能造成显著影响。

Effect of chemotherapy on antioxidant and immune function of patients with esophageal cancer

Objective：To explore effect of chemotherapy on lipid peroxidation,antioxidant and immune function of patients with esophageal cancer.Methods：A total of 79 cases of esophageal cancer treated with chemotherapy were selected.Immune function,indicators of lipid peroxidation and antioxidant effects before and after chemotherapy were measured,the,and their relevance were analyzed.Results：MDA and aIL-2Rlevels were significantly higher than before treatment（P〈0.05）,GSH-Px and IL-6levels were significantly lower than those before treatment（P〈0.05）,but no significant difference in T-SOD was observed after chemotherapy（P〉0.05）.Before chemotherapy,aIL-2Rlevels was no significantly correlated with T-SOD or MDA,but was negatively correlated with GSH-Px;before chemotherapy IL-6levels was negatively correlated with MDA,positively correlated with T-SOD,but not correlated with GSH-Px.The difference of aIL-2Rwas negatively correlated with difference of GSH-Px,positively correlated with difference of MDA,and not correlated with difference of T-SOD.The difference of IL-6was positively correlated with difference of T-SOD,not correlated with difference of MDA or GHS-Px.Conclusions：Chemotherapy has significant effect on lipid peroxidation and antioxidant effects of patients with esophageal cancer,and has significant impact on the immune function of patients.