左氧氟沙星在难治性肺结核患者中的应用效果与安全性观察

目的：探讨左氧氟沙星治疗难治性肺结核患者的临床效果和安全性。方法：回顾性分析我院收治的70例难治性肺结核患者的临床资料，根据治疗方法不同分为治疗组和对照组各35例，对照组患者采用2HRZSE／6HRE化疗，治疗组患者在对照组治疗的基础上加用左氧氟沙星，比较两组患者治疗后的临床疗效和安全性。结果：治疗组患者的总有效率为94．29％，对照组患者的总有效率77．14％，两组患者的总有效率具有显著性差异，P＜0．05；治疗后2个月末、5个月末、8个月末，治疗组患者的痰菌转阴率和胸片检查空洞吸收／缩小率均显著高于对照组，P＜0．05；治疗组患者的不良反应发生率为8．57％，显著低于对照组患者的17．14％，P＜0．05。结论：左氧氟沙星治疗难治性肺结核患者，显著提高患者的痰菌转阴率和空洞吸收／缩小率，临床疗效显著，且安全性高。

The Observation of the Efficacy and Safety for Levofloxacin in Patients with Refractory Pulmonary Tuberculosis

Objective ：To investigate the clinical efficacy and safety for levofloxacin in patients with refractory pulmonary tuberculosis .Methods ：The clinical data of 70 cases of patients with refractory pulmonary tuberculosis in our hospital was taken for retrospective analysis .According to the different treatment methods ,they were divided into the treatment group and the control group ,and 35 patients in each group .The control group was treated with 2HRZSE/6HRE chemotherapy ,and the treatment group was taken with levofloxacin based on the therapy of control group .The clinical efficacy and safety of the two groups were compared after treatment .Results：The total effective rate of the treatment group was 94 .29% ,and the total efficiency rate in the control group was 77 .14% ,the total efficiency rates of the two groups were with statistical significant differences ,P〈0 .05 .After treatment of 1 month ,3 months ,6 months ,the rate of patients treated sputum negative and chest X-ray inspection holes or narrow absorption rate in the treatment group was significantly higher than the control group ,P〈0 .05 .The adverse reaction incidence in the treatment group was 8.57% ,significantly lower than the incidence of adverse reactions in the control group of 17 .14% ,P〈 0 .05 .Conclusion：Levofloxacin in the treatment of refractory tuberculosis patients can significantly improve the patient ’s sputum negative absorption rate and empty or out rate ,the clinical effect is significant and it is with high safety .