膝关节镜清理术联合透明质酸钠治疗骨性关节炎的疗效观察

目的：探讨膝关节镜清理术联合透明质酸钠治疗骨性关节炎的临床疗效。方法：选择我院治疗的92例骨性关节炎患者，随机分为治疗组和对照组各46例，对照组患者仅采用膝关节清理术治疗，治疗组采用膝关节清理术联合透明质酸钠治疗，比较两组患者的临床疗效、治疗前、后膝骨关节滑液中IL-1和血清中NO含量以及手术前、后患者Lysholm功能评分。结果：治疗组患者的总有效率为91．30％，对照组为78．26％，两组总有效率差异具有显著性，P＜0．05；治疗后治疗组患者膝骨关节滑液中IL-1含量和血清中NO含量均显著低于对照组，P＜0．05；治疗组患者的Lysholm功能评分术后3个月和术后12个月分别为（75．18±15．10）分和（81．21±10．37）分，均显著高于对照组，P＜0．05。结论：膝关节镜清理术联合透明质酸钠治疗骨性关节炎临床效果显著。

The Observation of the Efficacy of Arthroscopic Knee Debridement Combined Sodium Hyaluronate in the Treatment of Os-teoarthritis

Objective ：To explore the clinical efficacy of arthroscopic knee debridement combined sodium hyaluronate in the treatment of osteoarthritis .Methods ：92 patients with osteoarthritis in our hospital were chosen .They were randomly divided into the treatment group and the control group ,and 46 patients in each group .The control group was only taken with knee debridement ,and the treatment group was taken with sodium hyaluronate knee joint debridement treatment .The clinical efficacy ,knee joint synovial fluid and serum IL-1 and NO levels before and after treatment ,Lysholm functional score before and after surgery for the two groups were compared .Results：The total efficiency rate of the treatment group was 91 .30% ,78 .26% in the control group ,the differences of the total efficiency rate of the two groups were significant ,P〈0 .05 .After treatment ,the IL-1 content in the knee joint synovial fluid and NO levels in the serum in the observation group were significantly higher than the control group ,P〈0 .05 .The Lysholm functional scores for the treatment group after 3 months and 12 months were （75 .18 ± 15 .10） points and （81 .21 ± 10 .37） points , which were significantly higher than the control group ,P〈0 .05 .Conclusion：The clinical effect of arthroscopic knee debridement combined sodium hyaluronate in the treatment of osteoarthritis is significant .