Expression and clinical significance of dendritic cell and transforming growth factor-beta 1 in cervical cancer

Cervical cancer and precancerous cervical lesionsare major problems in women's health.Clinical,molecu-lar and epidemiological investigations have identifiedhuman papillomavirus(HPV)as a major cause of cer-vical cancer1].Although HPV infection is very com…

Expression and clinical significance of dendritic cell and transforming growth factor-beta 1 in cervical cancer

Objective:To explore the density and mature status of Dendritic cell(DC) in cervical cancer and correlation with the expression of transforming growth factor-beta 1(TGF-β1).Methods:Streptavidin-peroxidase(SP) immunohistochemistry methods were used to detect S-100 DC and the expression of TGF-β1 in 20 normal cervical tissues and 53 cervical cancer tissues without any sort of chemotherapy or radiation therapy prior to resection.Medical records were reviewed,clinicopathological variables were retrieved and used for analysis.Results:Two types of DC were observed under the microscope.The expression of DC in cervical cancer was significantly higher than that in normal tissues(23.34 cells/mm2 vs 29.91 cells/mm2,P＜0.05),and significantly higher in early stage than that in advanced stage(P＜0.05).The expression of TGF-β1 was significantly higher in cervical cancer than that in normal tissues (P＜0.025).However,there was no correaction between TGF-β1 and lymph nodes metastasis.The index of DC in cervical cancer was negatively correlated to the expression of TGF-β1 in tumor cells (r=-0.8875,P=0.0001).Conclusion:Maturation of DC in cervical cancer is inhibited.The decreased number of DC and the higher expression of TGF-β1 are due to the failure of the immunity,these may play an important role in the development of the cervical cancer.