Evaluación de la complejidad de la activación miocárdica durante la fibrilación ventricular. Estudio experimental |
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Authors: | Luis Such-Miquel Francisco J Chorro Juan Guerrero Isabel Trapero Laia Brines Manuel Zarzoso Germán Parra Carlos Soler Irene del Canto Antonio Alberola Luis Such |
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Institution: | 1. Departamento de Fisioterapia, Universitat de València, Valencia, España;2. Departamento de Medicina, Universitat de València, Valencia, España;3. Servicio de Cardiología, Hospital Clínico Universitario, INCLIVA, Valencia, España;4. Departamento de Electrónica, Universitat de València, Valencia, España;5. Departamento de Enfermería, Universitat de València, Valencia, España;6. Departamento de Fisiología, Universitat de València, Valencia, España |
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Abstract: | Introduction and objectivesAn experimental model is used to analyze the characteristics of ventricular fibrillation in situations of variable complexity, establishing relationships among the data produced by different methods for analyzing the arrhythmia.MethodsIn 27 isolated rabbit heart preparations studied under the action of drugs (propranolol and KB-R7943) or physical procedures (stretching) that produce different degrees of change in the complexity of myocardial activation during ventricular fibrillation, use was made of spectral, morphological, and mapping techniques to process the recordings obtained with epicardial multielectrodes.ResultsThe complexity of ventricular fibrillation assessed by mapping techniques was related to the dominant frequency, normalized spectral energy, signal regularity index, and their corresponding coefficients of variation, as well as the area of the regions of interest identified on the basis of these parameters. In the multivariate analysis, we used as independent variables the area of the regions of interest related to the spectral energy and the coefficient of variation of the energy (complexity index=–0.005×area of the spectral energy regions –2.234×coefficient of variation of the energy+1.578; P=.0001; r=0.68).ConclusionsThe spectral and morphological indicators and, independently, those derived from the analysis of normalized energy regions of interest provide a reliable approach to the evaluation of the complexity of ventricular fibrillation as an alternative to complex mapping techniques.Full English text available from:www.revespcardiol.org/en. |
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Keywords: | EN energí a normalizada FD frecuencia dominante FV fibrilació n ventricular ICM í ndice de complejidad IR í ndice de regularidad RDI regiones de interé s |
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