Calidad de vida relacionada con la salud en una cohorte nacional de pacientes con hipertensión arterial pulmonar o hipertensión pulmonar tromboembólica crónica |
| |
Authors: | Antonio Roman Joan Albert Barbera Maria Jesús Castillo Rocío Muñoz Pilar Escribano |
| |
Institution: | 1. Hospital Vall d’Hebrón, CIBERES, Barcelona, España;2. Hospital Clínic, CIBERES, Barcelona, España;3. Hospital Virgen del Rocío, Sevilla, España;4. Pfizer Departamento Médico, Madrid, España;5. Hospital 12 de Octubre, REDINSCOR, Madrid, España |
| |
Abstract: | BackgroundPatients with pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH) experience impaired health-related quality of life (HRQL). The objective of this study was to evaluate HRQL in a nation-wide sample.Patients and methodsThis is a prospective, multicenter, non-interventional study of HRQL including 139 (89%) PAH and 17 (11%) CTEPH patients (women 70.5%; mean age, 52.2) recruited from 21 Spanish hospitals. 55% had idiopathic PAH, 34% other PAH and 11% CTEPH. HRQL was measured using the Short Form 36 Health Survey (SF-36) and EuroQoL-5D (baseline and after 6 months).ResultsHRQL in the patients with PAH or CTEPH was impaired. The physical component of SF-36 and the EuroQol-5D correlated with the functional class (FC). Mean EuroQol-5D visual analogical scale (EQ-5D VAS) scores were 73.5 ± 18.4, 62.9 ± 20.7 and 51.3 ± 16.0 (P < .0001) in patients with FC I, II and III, respectively. Every increase of one FC represented a loss of 4.0 on the PCS SF-36 and a loss of 9.5 on the EQ-5D VAS. Eight patients who died or received a transplant during the study period presented poorer initial HRQL compared with the rest of the population. No significant changes in HRQL were observed in survivors after 6 months of follow-up.ConclusionsHRQL is impaired in this population, especially in PAH/CTEPH patients near death. HRQL measurements could help predict the prognosis in PAH and CTPH and provide additional information in these patients. |
| |
Keywords: | Hipertensió n arterial pulmonar Hipertensió n pulmonar tromboembó lica cró nica Calidad de vida relacionada con la salud Cuestionario Short Form 36 abreviado Cuestionario EuroQol-5D |
本文献已被 ScienceDirect 等数据库收录! |
|