Pregnancy complications predict thrombotic events in young women with essential thrombocythemia |
| |
| Authors: | Maria Luigia Randi Irene Bertozzi Elisa Rumi Chiara Elena Guido Finazzi Nicola Vianelli Nicola Polverelli Marco Ruggeri Alessandro Maria Vannucchi Elisabetta Antonioli Federico Lussana Alessia Tieghi Alessandra Iurlo Elena Elli Marco Ruella Fabrizio Fabris Mario Cazzola Tiziano Barbui |
| |
| Affiliation: | 1. Dept of Medicine -DIMED, Internal Medicine, University of Padua, Padua, Italy;2. Department of Hematology, University of Pavia, Pavia, Italy;3. Hematology Division, Bergamo, Italy;4. Institute of Hematology “Lorenzo e Ariosto Seràgnoli,”, Department of Hematology and Oncology, Bologna, Italy;5. Department of Hematology, Vicenza, Italy;6. Division of Hematology, University of Florence, Florence, Italy;7. Hematology Unit, Department of Oncology, Arcispedale Santa Maria Nuova—IRCCS, Italy;8. Hematology Division, Fondazione Ca' Granda IRCCS, Milan, Italy;9. Hematology Division, San Gerardo Hospital, Monza (Milan), Italy;10. Department of Hematology and Cell Therapy, University of Torino, Torino, Italy;11. Hematology Division, Research Foundation, Bergamo, Italy |
| |
| Abstract: | Although Philadelphia‐negative myeloproliferative neoplasms (MPNs) occur typically in middle to advanced age, any age group may be affected, posing a challenge for their management during pregnancy when they occur in young females. There is a high incidence of thromboembolic events and pregnancy complications in patients with myeloproliferative neoplasms, and a possible relationship between these complications is a matter of concern. The aim of this article was to correlate thrombosis and pregnancy outcome in 158 females with ET experiencing 237 pregnancies. Seven patients had a thrombotic event before their first pregnancy, one of them ended (14.3%) in a miscarriage. Among the 151 patients with no history of thrombosis before they became pregnant, 40 (26.5%) had a miscarriage (P = NS). Eighteen patients (11.4%) developed major thrombotic complications (12 splanchnic vein, 1 cerebral vein, 2 coronary syndromes, and 3 strokes) after at least one pregnancy (4 uneventful and 14 complicated). The occurrence of thrombosis was significantly more frequent (P < 0.001) in patients with a history of pregnancy complications (28%) than in those experiencing a normal pregnancy and delivery (3.7%). Pregnancy complications in women with ET are associated with a higher risk of subsequent thromboses, so pregnant women with this neoplasm who miscarry need to be carefully monitored. Am. J. Hematol. 89:306–309, 2014. © 2013 Wiley Periodicals, Inc. |
| |
| Keywords: | |
|
|
