Effect of Phyllanthus amarus on duck hepatitis B virus replication in vivo |
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Authors: | J Z Niu Y Y Wang M Qiao E Gowans P Edwards S P Thyagarajan I Gust S Locarnini |
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Institution: | Hepatitis Research Unit, Macfarlane Burnet Centre for Medical Research, Fairfield Hospital, Victoria, Australia. |
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Abstract: | Nine ducks congenitally infected with the duck hepatitis B virus (DHBV) were treated either orally (four ducks for 10 weeks) or intraperitoneally (five ducks for 12 weeks) with the Indian traditional herbal remedy Phyllanthus amarus. Compared to placebo-treated control ducks, these treatments did not result in a reduction of circulating viral DNA in the serum or in the level of viral DNA replication in the liver. In two of the five intraperitoneal-treated ducks, a reduction in the levels of duck hepatitis B surface antigenaemia (DHBsAg) was observed. The data strongly suggest that Phyllanthus amarus has no significant inhibitory effect on DHBV DNA replication and only a minor effect on DHBsAg production. |
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Keywords: | Phyllanthus amarus duck hepatitis B virus antiviral therapy traditional remedies animal models |
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