帕罗西汀对慢性精神分裂症患者认知功能的影响

目的探讨帕罗西汀对恢复期慢性精神分裂症患者认知功能障碍的影响。方法将60例恢复期慢性精神分裂症患者随机分为两组各30例．两组在原抗精神病药物治疗的基础上研究组联合帕罗西汀治疗．对照组联合安慰剂治疗．疗程8w,采用简明精神病量表．韦氏成人智力量表．韦氏记忆量表．威斯康星卡片分类测验进行评定分析。结果治疗8w末,研究组认知功能改善显著优于对照组．两组治疗后各量表同期评分比较均有显著性差异（P〈0．05）。结论帕罗西汀可改善慢性精神分裂症患者的认知功能。

The influences of paroxetine on the cognitive function of chronic schizophrenics

Objective To explore the influences of paroxetine on cognitive function of chronic schizophrenia in convalescent period. Methods 60 convalescent chronic schizophrenics were randomly divided into two groups(each n=30): research group took previous antipsychotics plus paroxetine and control group plus placebo for 8 weeks. Assessments and analyses were conducted with the Brief Psychiatric Rating Scale(BPRS),the Wechsler Adult Intelligence Scale(WAIS), the Wechsler Memory Scale(WMS) and the Wiscons in Card Sorting Test(WCST) before and after treatment. Results After 8-week treatment, cognitive improvement was significant in the research group than in the control group, in different period there were significant differences in scores of all scales between the 2 groups(P<0.05). Conclusion Paroxetine can improve the cognitive function of chronic schizophrenics.