Synthesis,Polymorphism, and Insecticidal Activity of Methyl 4‐(4‐chlorophenyl)‐8‐iodo‐2‐methyl‐6‐oxo‐1,6‐dihydro‐4H‐pyrimido[2,1‐b]quinazoline‐3‐Carboxylate Against Anopheles arabiensis Mosquito |
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| Authors: | Katharigatta N. Venugopala Susanta K. Nayak Raquel M. Gleiser Mariela E. Sanchez‐Borzone Daniel A. Garcia Bharti Odhav |
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| Affiliation: | 1. Department of Biotechnology and Food Technology, Faculty of Applied Sciences, Durban University of Technology, Durban, South Africa;2. Department of Chemistry, Visvesvaraya National Institute of Technology, Nagpur, Maharashtra, India;3. CREAN‐IMBIV (CONICET‐UNC), Universidad Nacional de Córdoba, Córdoba, Argentina;4. FCEFyN, Universidad Nacional de Córdoba, Córdoba, Argentina;5. Instituto de Investigaciones Biológicas y Tecnológicas (IIBYT), CONICET‐Universidad Nacional de Córdoba, Córdoba, Argentina |
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| Abstract: | Mosquitoes are the major vectors of pathogens and parasites including those causing malaria, the most deadly vector‐borne disease. The negative environmental effects of most synthetic compounds combined with widespread development of insecticide resistance encourage an interest in finding and developing alternative products against mosquitoes. In this study, pyrimido[2,1‐b]quinazoline derivative DHPM 3 has been synthesized by three‐step chemical reaction and screened for larvicide, adulticide, and repellent properties against Anopheles arabiensis, one of the dominant vectors of malaria in Africa. The title compound emerged as potential larvicide agent for further research and development, because it exerted 100% mortality, while adulticide activity was considered moderate. |
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| Keywords: | antimosquito properties crystallography polymorphism pyrimido[2,1‐b]quinazoline synthesis |
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