Cardioprotective effect of novel sulphonamides‐1,3,5‐triazine conjugates against ischaemic–reperfusion injury via selective inhibition of MMP‐9

Diseases affecting cardiovascular system are ranked as a top most cause of morbidity and mortality. Herein, a novel class sulphonamides‐1,3,5‐triazine conjugates have been synthesized and tested for inhibitory activity against MMP‐2 and MMP‐9. The results of the study showed that these molecules efficiently inhibit MMP‐9 than MMP‐2, revealing compound 8e as the most potent inhibitor (IC₅₀ = 2.34 ± 0.56 nm ). Due to involvement of MMP‐9 in many cardiovascular diseases, particularly in myocardial ischaemia (MI), compound 8e was further subjected for the determination of the protective effect on isoproterenol (ISO)‐induced myocardial injury in rats.