浸润性乳腺癌中CK5/6、EGFR以及激素受体表达的相关性分析

目的：了解浸润性乳腺癌中CK5/6、EGFR以及激素受体的表达情况及其相关性.方法：采用HE、免疫组化（EnVision法）检测146例浸润性乳腺癌.结果：146例患者均为女性,年龄33-82岁,平均54岁.组织学上部分肿瘤细胞显著多形性,核分裂象多见.免疫组化：146例浸润性乳腺癌中31例为ER、PR、HER2三阴性乳腺癌.CK5/6在浸润性乳腺癌及三阴性乳腺癌中的表达率分别为17.8%（26/146）和54.8%（17/31）,EGFR在CK5/6阳性和CK5/6阴性乳腺癌中的表达率分别为65.3%（17/26）和16.6%（20/120）.Ki-67在CK5/6阳性乳腺癌中的表达率显著高于CK5/6阴性乳腺癌中的表达率.结论：基底细胞样型乳腺癌在三阴性乳腺癌中发病率较高;Ki-67在基底细胞样型乳腺癌中高表达率提示该肿瘤预后差.

Correlation analysis of the expression of CK5/6, EGFR and hormone receptors in invasive breast carcinomas

Objective：To observe the expression and correlation of CKS/6,EGFR and hormone receptors in invasive breast carcinomas. Methods ： One hundred and forty six cases of invasive breast carcinoma were investigated with HE staining and EnVision immunostaining. Results：All patients were females ,33 -82 years in age （mean 54 years）. Histologically,part of the tumors showed marked cellular pleomorphism and high mitotic index. Immunohistochemical- ly ,31 cases were triple negative （ ER -/PR -/HER2 - ） among the 146 cases of invasive breast carcinomas. CK5/6 was positive in 17.8% （26/146） of invasive breast carcinomas and 54.8% （ 17/31 ） of triple - negative breast carcinomas. EGFR was positive in 65.3% （17/26） of CK5/6 positive breast carcinomas and in 16.6% （20/120） of CK5/6 negative breast carcinomas. The expression of Ki - 67 was more higher in CK5/6 positive breast carcinomas than in CK5/6 negative breast carcinomas. Conclusion： Basal - like breast carcinomas have higher incidence in triple -negative breast carcinomas;high expression of Ki -67 in basal -like breast carcinomas indicates poor prognosis.