半夏厚朴汤加味治疗海洛因依赖脱毒后稽延性戒断症状的临床观察

目的观察半夏厚朴汤加味(简称中药)对海洛因依赖脱毒后稽延性戒断症状的治疗作用。方法将187例吸毒者随机分成3组，即对照组58例、治疗A组62例、治疗B组67例。3组均采用盐酸洛啡西定(LFX)脱毒治疗12天，脱毒后对照组服模拟制剂60天，治疗A组脱毒后服用中药60天，治疗B组从服用LFX脱毒开始即服用中药至脱毒后60天，两治疗组停用中药10天后，分别观察1周内3组相关稽延性戒断症状并评分，1年后尿检调查复吸情况。结果稽延性戒断症状评分，治疗B组低于治疗A组(P<0．01)，而治疗A组又低于对照组(P<0．01)。1年后复吸率治疗B组明显低于对照组和治疗A组(P<0．05)。结论半夏厚朴汤加味可改善海洛因依赖脱毒后的稽延性戒断症状。尽管复吸因素很复杂，但有效控制早期戒断症状和中期稽延性戒断症状是防止复吸的有效措施之一。

Clinical Observation on Effect of Modified Banxia Houpu Decoction in Treating Patients with Protracted Heroin Abstinence Syndrome

To observe the therapeutic effect of Modified Banxia Houpu Decoction (MBHD) in treating heroin abusers with protracted abstinence syndrome. Methods One hundred and eighty-seven heroin abusers were randomly divided into three groups, the 58 patients in the control group, 62 in the treated group A and 67 in the treated group B. All were detoxified with lofexidine hydrochloride (LFX)tablet for 12 days. MBHD was given to the two treated groups, the medication started from the beginning of detoxification in the group B, and from the end of detoxification in group A for 60 days. To the control group, an imitate preparation was given. The observation was carried out 10 days after withdrawal of medication, and the protracted abstinence related symptoms were observed and scored. And the condition of re-abusing in patients were investigated through urinary examination one year later. Results The heroin abusers' protracted abstinence symptom score in the treated group was significantly lower than that in the control group (P<0.01), and comparison of the scores between the two treated groups also showed significant difference (A