ER、PR受体和DNA对乳腺癌预后的影响

本文用ＰＡＰ法和流式细胞术（ＦＣＭ）对３２例乳腺浸润性导管癌激素受体、ＤＮＡ进行测定，并将其结果配对研究。结果发现ＥＲ阳性２１例（６５．６％），ＰＲ阳性２０例６２．４％，二倍体９例（２８．１％），异倍体２３例（７１．９％），其中四倍体５例（１５．６％）。配对研究发现ＥＲ阳性与ＳＰＦ，ＰＩ呈负相关（Ｐ＜０．０１），ＰＲ阳性与ＳＰＦ呈负相关（Ｐ＜０．０５），与ＰＩ无相关性。二倍体，异倍体之间ＳＰＦ、ＰＩ、ＥＲ、ＰＲ无显著性差异。将四倍体从异倍体中排除，再比较发现二倍体ＳＰＦ值明显低于异倍体（Ｐ＜０．０５），ＰＩ值差异变大，但无统计学意义。

Correlation of ER and PR and DNA in breast cancer

The estrogen receptors(ER) and the progesterone receptors(PR) and DNA were detected immunohistochemically(PAP method) and flow cytometrically(FCM) in 32 cases of infiltrating carcinoma of lactife-rous duct.The results showed ER was positive in 21 cases(65.6%), PR positive in 20 cases(62.4%),diploidy positive in 9(28.1%),hetero- ploidy positive in 23 cases(71.9%).In the latter,5 were tetraploid(15.6%).The study gave a negative correlationship between ER positive,S-phase fraction(SPF) and proliferative index(PI)(p<0.01),and a significant negative relationship betweon PR positive and SPF(P<0.05). But there was no correlationship with PI.The SPF,PI,ER and PR was not significantly different between diploidy and heteroploidy.If tetraploidycases were excluded from heteroploidy ones.then the SPF level of diploidy was significantly lower than that of heteroploidy(p<0.05).PI level of diploidy had larger. variation but there is no stastical singficant meaning.