Synthesis and beta-adrenergic blocking activity of oxipropanolamines of 3,4-dihydro-3-oxo-2H(1,4)benzothiazine |
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| Authors: | V Cecchetti A Fravolini R Fringuelli F Schiaffella G Mascellani P G Pagella P L Rugarli |
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| Affiliation: | Istituto di Chimica Farmaceutica e Tecnica Farmaceutica-Università di Perugia, Italy. |
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| Abstract: | The synthesis of a series of oxypropanolamines of 3,4-dihydro-3-oxo-2H(1,4)benzothiazine is reported. Some of these compounds proved more potent than propranolol and carteolol as beta-adrenergic blocking agents in in vitro tests. The 8-(3-tert-butylamino-2-hydroxy)propoxy-3,4-dihydro-3-oxo-2H(1,4) benzothiazine fumarate (XVI a), which gave better results, confirmed its remarkable activity in in vivo tests. |
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