| ECGF生物活性与肝素的相关性研究 |
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| 引用本文： | 邢伟,刘素媛,孙黎光,许秀珍,陈日新,王跃忠,张亚佳,董玉兰. ECGF生物活性与肝素的相关性研究[J]. 中国医科大学学报, 1996, 0(3) |
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| 作者姓名： | 邢伟 刘素媛 孙黎光 许秀珍 陈日新 王跃忠 张亚佳 董玉兰 |
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| 作者单位： | 沈阳基础医学院生物化学教研室，沈阳基础医学院实验病理学研究室 |
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| 摘 要： | 观察肝素与内皮细胞生长因子（ＥｎｄｏｔｈｅｌｉａｌｃｅｌｌＧｒｏｗｔｈＦａｃｔｏｒ。ＥＣＧＦ）的分离、生物活性及促创伤愈合作用的相关性。结果表明：用肝素亲和层析分离ＥＣＧＦ纯度高、产量多；肝素可使ＥＣＧＦ生物活性增加；另外，在动物实验中，肝素与ＥＣＧＦ合用可使创伤提前愈合。
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| 关 键 词： | 内皮细胞生长因子；肝素 |
The Correlation Between Endothelial Cell Growth Factor and Heparin |
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| Xing Wei,Wang Yuezhong,LiuSuyuan,et al. The Correlation Between Endothelial Cell Growth Factor and Heparin[J]. Journal of China Medical University, 1996, 0(3) |
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| Authors: | Xing Wei Wang Yuezhong LiuSuyuan et al |
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| Abstract: | ndothelial cell growth factor(ECGF)derived from bovine brain was purified by the heparin affini-ty chromatography. Heparin potentiated the biological activity of ECGF. The biological activity ofECGF in HUVEC could be approximately 2.5 times as large as the control. Results of wound healing inrat models suggested that haparin could accelerate significantly the bioactivity of ECGF. The amount ofcapillary endothelial cells and fibroblast cells in granular tissue was markedly increased. |
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| Keywords: | endothelial cell growth factor heparin |
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