多囊卵巢综合征致不孕50例临床分析

目的：回顾性分析不孕门诊多囊卵巢综合征（PCOS）患者的不孕因素，探讨对PCOS不孕的综合治疗方法。方法：选择2009年1月—2011年4月收治的PCOS患者50例为研究对象，分析PCOS致不孕的因素，并总结临床治疗的经验。结果：50例患者中，39例有卵泡发育成熟，占78.0%；妊娠30例，占60.0%；先兆流产5例，占16.7%；稽留流产5例，占16.7%；2例出现OHSS，占6.7%；双胎妊娠1例，占3.3%；异位妊娠2例，占6.7%。23例顺利分娩。结论：PCOS是发病多因性、临床表现呈多态性的内分泌综合征，病理机制涉及高雄激素血症、胰岛素抵抗及高胰岛素血症，因此，临床上应采取综合方法治疗PCOS导致的不孕症。

Clinical Analysis of PCOS Infertility of 50 Cases

Objective：To analyze retrospectively the infertile factors of patients with polycystic ovary syndrome （PCOS） and the pathological mechanism, and to discuss its comprehensive therapy. Methods：Clinical analysis of the pathological mechanism of infertility induced by PCOS in 50 PCOS patients was did from infertility clinic in our hospital from Jan-09 to Apr-11，including the comprehensive treatment. Results：In 50 cases, there were 39 cases with mature follicles（78.0%），30 cases of pregnant（60.0%），5 cases of threatened abortion（16.7%），5 cases of missed abortion（16.7%），2 cases of ovarian hyperstimulation syndrome（OHSS）（6.7%），1 case of twin pregnancy（3.3%），2 cases of ectopic pregnancy （6.7%），23 cases were labored successfully. Conclusions：PCOS is a endocrine disorder of multiple etiological factors and clinical manifestations including hyperandrogenism，insulin resistance and hyperproinsulinemia. So the treatment for PCOS infertility should be comprehensive.