Overexpression of Gli1 in cancer interstitial tissues predicts early relapse after radical operation of breast cancer |
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Authors: | Ying-Hua Li Hai-Feng Gao Yan Wang Fang Liu Xiao-Feng Tian Yang Zhang |
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Affiliation: | Ying-Hua Li (Department of Oncology, Second Affiliated Hospital of Dalian Medical University, Dalian 116023, China);Hai-Feng Gao (Department of Urology, Central Hospital of Dalian City, Dalian 116033, China);Yan Wang (Laboratory Center, Second Affiliated Hospital of Dalian Medical University, Dalian 116023, China);Fang Liu (Department of Oncology, Second Affiliated Hospital of Dalian Medical University, Dalian 116023, China);Xiao-Feng Tian (Department of General Surgery, Second Affiliated Hospital of Dalian Medical University, Dalian 116023, China);Yang Zhang (Department of Oncology, Second Affiliated Hospital of Dalian Medical University, Dalian 116023, China); |
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Abstract: | Objective To investigate whether Gli1 expression is important in relapse after radical operation of breast cancer. Methods Using immunohistochemistry, Gli1 expression was analyzed in human primary breast cancer (n=284) and paracancerous tissues (n=20), and also in local lymph nodes (n=28) and metastatic lymph nodes (n=28). Results Initial analysis of Gli1 expression in a small cohort of 20 breast tumors and their paracancerous tissues showed a tendency towards Gli1 overexpression in breast cancer tissues (P<0.001). Further, Gli1 expression in 284 breast cancer tissue samples was analyzed and a significant correlation was found between increased expression of nuclear Gli1 and unfavorable recurrence-free survival (RFS) (P<0.05). The nuclear expression of Gli1 in metastatic lymph nodes following relapse after radical operation was much higher than that in the local lymph nodes of primary carcinoma (P<0.05). Most interestingly, the expression of Gli1 was much higher in the interstitial tissues of the relapsed group than of the non-relapsed group (P<0.001). Conclusions Breast cancer shows a high prevalence of Gli1 expression, which is significantly correlated with aggressive features and unfavorable RFS. Nuclear Gli1 overexpression, especially in the interstitial tissues, signified early relapse after radical operation of breast cancer. |
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