Effects of the Japanese herbal medicine 'Sho-saiko-to' as a cytokine inducer |
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| Authors: | Yamashiki M Nishimura A Sakaguchi S Suzuki H Kosaka Y |
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| Affiliation: | aDepartment of Laboratory Medicine, Mie University School of Medicine, 2–174, Edobashi, Tsu, Mie 514, Japan;bDepartment of Internal Medicine, Suzuka Central General Hospital, Suzuka, Mie 510, Japan;cDepartment of Gastroenterology, Fukuoka University Tsukushi Hospital, Tsukushino, Fukuoka 818, Japan;dDivision of Gastroenterology, University of Maryland, Baltimore, MD 21201, USA |
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| Abstract: | The herbal medicine, Sho-saiko-to (TJ-9), has been widely prescribed to chronic viral liver disease patients in Japan. This study examined the inductions of such sytokines as interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), and granulocyte-colony stimulating factor (G-CSF), on some fractions of peripheral blood mononuclear cells (PBMC) by TJ-9 and each of its seven components. IL-1β, TNF-α, and G-CSF were highly induced by scutellaria root and glycyrrhiza root on monocytes/macrophages. By repeating the same experiments using taxol (an LPS antagonist)-treated substances, authors confirmed that these inductions were not attributable to the presence of quite low LPS in TJ-9 solution, and the cytokine inductions are the specific effect of TJ-9. Because TJ-9's macrobiotic effect in liver cirrhosis patients has been proven statistically in an etiological study, TJ-9 could be a new important therapy in chronic liver diseases. |
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| Keywords: | Herbal medicine Sho-saiko-to Interleukin-1β Tumor necrosis factor-α Granulocyte-colony stimulating factor Cytokine inducer |
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