Increased regional brain concentrations of ceruloplasmin in neurodegenerative disorders |
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| Authors: | D.A. Loeffler P.A. LeWitt P.L. Juneau A.A.F. Sima H.-U. Nguyen A.J. DeMaggio C.M. Brickman G.J. Brewer R.D. Dick M.D. Troyer L. Kanaley |
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| Affiliation: | aDepartment of Medicine, Sinai Hospital, 6767 W. Outer Drive, Detroit, MI 48235, USA;bDepartments of Neurology and Psychiatry, Wayne State University School of Medicine, 4201 St. Antoine, Detroit, MI 48201, USA;cDepartment of Pathology, Wayne State University School of Medicine, 540 E. Canfield, Detroit, MI 48201, USA;dDepartment of Human Genetics, University of Michigan, Medical Science II M4708, Ann Arbor, MI 48109, USA;eHarvard-Longwood Neurology Program, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA;fHarvard Brain Tissue Resource Center, McLean Hospital, 115 Mill Street, Belmont, MA 02178, USA |
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| Abstract: | Ceruloplasmin (CP), the major plasma anti-oxidant and copper transport protein, is synthesized in several tissues, including the brain. We compared regional brain concentrations of CP and copper between subjects with Alzheimer's disease (AD, n = 12), Parkinson's disease (PD, n = 14), Huntington's disease (HD, n = 11), progressive supranuclear palsy (PSP, n = 11), young adult normal controls (YC, n = 6) and elderly normal controls (EC, n = 7). Mean CP concentrations were significantly increased vs. EC (P < 0.05) in AD hippocampus, entorhinal cortex, frontal cortex, and putamen, PD hippocampus, frontal, temporal, and parietal cortices, and HD hippocampus, parietal cortex, and substantia nigra. lmmunocytochemical staining for CP in AD hippocampus revealed marked staining within neurons, astrocytes, and neuritic plaques. Increased CP concentrations in brain in these disorders may indicate a localized acute phase-type response and/or a compensatory increase to oxidative stress. |
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| Keywords: | Acute phase protein Alzheimer's disease Ceruloplasmin Copper Huntington's disease Parkinson's disease Progressive supranuclear palsy |
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