Nitric oxide synthase-containing neurons in the hippocampus are preserved in trimethyltin intoxication |
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| Authors: | M. Ikeda H. Kanai M. Akaike S. Tsutsumi M. Sadamatsu A. Masui N. Kato |
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| Affiliation: | aDepartment of Physiological Chemistry, Graduate School, Tokyo Medical and Dental University, Yushima 1-5-45, Bunkyo, Tokyo 113, Japan;bDepartment of Psychiatry, Shiga University of Medical Science, Shiga, Japan;cPharma Research and Development Division, Hoechst Japan Ltd., Saitama, Japan |
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| Abstract: | We studied the effects of trimethyltin (TMT) (9 mg/kg, p.o.) on the nitric oxide synthase (NOS)-containing neurons in the rat hippocampus by NADPH-diaphorase histochemistry and a biochemical assay of NOS activity. TMT exposure caused the typical behavioral changes and a loss of the CA3/4 pyramidal cells, which were NADPH diaphorase-negative. The scattered interneurons and the CA1 pyramidal cells, which were NADPH diaphorase-positive, were spared. Hippocampal NOS activity showed no reduction in the TMT-treated rats compared with the controls. These results provide evidence of the preservation of the NOS-containing neurons in TMT intoxication. |
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| Keywords: | Trimethyltin Hippocampus Nitric oxide |
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