Extracellular dopamine in the rat ventral tegmental area and nucleus accumbens following ventral tegmental infusion of cocaine |
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Authors: | Shiouh-Yi Chen Robert L. Burger Maarten E.A. Reith |
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Affiliation: | Department of Biomedical and Therapeutic Sciences (formerly Basic Sciences), University of Illinois, College of Medicine, Box 1649, Peoria, IL 61656, USA |
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Abstract: | Rats were implanted with dual dialysis probes, one in the ventral tegmental area, and another one ipsilateral in the nucleus accumbens. Infusion of cocaine (10, 100, 1000 mM) into the ventral tegmental area gradually increased extracellular dopamine to 164, 329 and 991% of baseline in the ventral tegmental area, but reduced dopamine to 76, 47 and 38% of baseline in the nucleus acumbens. These results are consistent with cocaine-induced feedback regulation of dopamine cell activity involving somatodendritec impulse-regulating dopamine D2 autoreceptors. |
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Keywords: | Cocaine Dopamine somatodendrites Dopamine D2 autoreceptors Ventral tegmental area Nucleus accumbens Microdialysis |
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