| Study of neuropeptide Y in the plasma and skin tissue of patients with vitiligo |
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| 引用本文： | 曾维惠,谭升顺,郑焱,雷小兵. Study of neuropeptide Y in the plasma and skin tissue of patients with vitiligo[J]. 中国人民解放军军医大学学报, 2004, 19(3): 183-186 |
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| 作者姓名： | 曾维惠 谭升顺 郑焱 雷小兵 |
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| 作者单位： | Department of Dermatology，Second Hospital，Xi'an Jiaotong University，Department of Dermatology，Second Hospital，Xi'an Jiaotong University，Department of Dermatology，Second Hospital，Xi'an Jiaotong University，Department of Dermatology，Second Hospital，Xi'an Jiaotong University Xi'an 710004，China，Xi'an 710004，China，Xi'an 710004，China，Xi'an 710004，China |
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| 摘 要： | Vitiligoisacommondepigmentingdisorder.Thepathogenesishasnotyetbeenfullyelucidated .Therearethreeprevailingtheoriestoexplainthepathogenesisofvitil igo :theneuralhypothesis,theimmunehypothesisandthemelanocyteself destructionhypothesis .Thereisnowconv incingevidencethatneuralfactorshaveanimportantroleinthepathogenesisofvitiligo[1-6] .InordertomakefurtherstudyonthepossibleroleofneuropeptideY (NPY)inthepathogenesisofvitiligo ,wemeasuredthelevelsofNPYintheplasmaofpatientswithvitiligoandhealthyvol…
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| 关 键 词： | 神经肽Y 血浆 皮肤组织 白癜风 NPY 发病机理 |
Study of neuropeptide Y in the plasma and skin tissue of patients with vitiligo |
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| ZENG Wei-hui,TANG Sheng-shun,ZHENG Yan,LEI Xiao-bing. Study of neuropeptide Y in the plasma and skin tissue of patients with vitiligo[J]. Journal of Medical Colleges of PLA(China), 2004, 19(3): 183-186 |
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| Authors: | ZENG Wei-hui TANG Sheng-shun ZHENG Yan LEI Xiao-bing |
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| Affiliation: | ZENG Wei-hui,TANG Sheng-shun,ZHENG Yan,LEI Xiao-bing Department of Dermatology,Second Hospital,Xi'an Jiaotong University,Xi'an 710004,China |
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| Abstract: | Objective: To study the role of neuropeptide Y (NPY) in the pathogenesis of vitiligo. Methods: The levels of NPY in the plasma from patients with vitiligo and healthy volunteers were measured by 125I RIA Kit. The expression of NPY in normal skin tissues, uninvolved tissues and lesional tissues of vitiligo was detected by immunohistochemistry. Results: The levels of NPY in the patients with vitiligo of all types were significantly higher than that in the normal controls. In all types, the levels in active stage were significantly higher than those in stable stage. The expression of NPY was upregulated in lesions of patients with active vitiligo (P<0.01) compared with those in normal skin tissues and uninvolved tissues. There was significant difference of NPY expression between active stage and stable stage (P<0.01). Conclusion: These findings support the concept of neuropeptide involvement in vitiligo, especially in active vitiligo, and suggest that NPY may play a role in the pathogenesis of this disease. |
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| Keywords: | vitiligo neuropeptide plasma immunohistochemistry 125I RIA Kit |
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