| 脑梗死患者甘油三酯与纤溶活性异常的研究 |
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| 引用本文： | 王敏莲,文芳.脑梗死患者甘油三酯与纤溶活性异常的研究[J].血栓与止血学,2002,8(4):154-155. |
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| 作者姓名： | 王敏莲 文芳 |
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| 作者单位： | 武汉大学人民医院微循环杂志编辑部,武汉,430060 |
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| 摘 要： | 目的：探讨患血浆高甘油三酯与纤溶系统异常对脑梗死发病的危险度。方法：采用酶联免疫吸附双抗体夹心法、酶法、对51例脑梗死患及50例健康对照组血浆组织型纤溶酶原激活物（tPA)、纤溶酶原激活剂抑制物－1（PAI－1）和甘油三酯（TG）水平进行对比分析。结果：血浆高TG，高PAI－1与低tPA含量变化为脑梗死患异常变化的特征，与正常组相比差异有显性（P＜0．01），结论：高甘油三酯通过改变纤溶活性是诱发脑梗死疾病发生，发展的危险的因素之一。
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| 关 键 词： | 脑梗死 甘油三酯 纤溶酶原激活物 纤溶酶原激活剂抑制物－1 危险因素 作用机制 |
| 文章编号： | 1009-6213(2002)04-0154-02 |
| 修稿时间： | 2002年5月12日 |
Research Between Triglyceride and Plasminogen Activity on Abnormal in Patients with Cerebral Infarction |
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| WAJVG Mei-lian,WEN FangThe Prople's Hopsital of Wuhan University,Wuhan.Research Between Triglyceride and Plasminogen Activity on Abnormal in Patients with Cerebral Infarction[J].Chinese Journal of Thrombosis and Hemostasis,2002,8(4):154-155. |
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| Authors: | WAJVG Mei-lian WEN FangThe Prople's Hopsital of Wuhan University Wuhan |
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| Institution: | WAJVG Mei-lian,WEN FangThe Prople's Hopsital of Wuhan University,Wuhan 430060 |
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| Abstract: | Objective: To study the risk factor of triglyceride and plasminogen activity on abnormal in patients with cerebral infarction. Methods: Using ELISA and enzyme methods, the content of tissue plasminogen activitor(t-PA) plasminogen activitorinhibator-1(PAI-1) and triglyceride(TG) in 51 patients with cerebral infarction, and 50 normal controls were analyse. Results: The changes of high TG, PAI-1 and low level t-PA were most significant abnormal charctor of cerebral infarction. Conclusion: High TG may an important role in the pathogenesis of cerebral infarction by in duing fibrinolytic dysufunction. |
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| Keywords: | Cerebral infarction Triglyceride Tissue plasminogen activitor(t-PA) Plasminogen ac-tivitorinhibator-1(PAI-1) |
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