三维适形放射治疗在非小细胞肺癌综合治疗中的价值

[目的]探讨三维立体定向放射治疗在非小细胞肺癌综合治疗中的价值。[方法]研究组52例采用前胸后背相对野常规放射治疗,剂量36Gy,18次,2Gy/次,3.6周完成;然后进行三维适形放射治疗,剂量30～42Gy,3Gy/次,10～14次。对照组52例采用常规放射治疗,剂量60～62Gy,2Gy/次,30～31次。两组患者放射治疗结束后,均进行化疗。[结果]研究组放射性食管炎和放射性肺炎发生率显著低于对照组(P<0.05,P<0.01)。研究组近期有效率(CR PR)(86.5%,45/52)显著高于对照组(51.9%,27/52)(P<0.05)。研究组1、2年局部控制率(78.8%,51.9%)显著高于对照组(46.2%,15.4%)(P<0.01)。研究组1、2年生存率(63.46%,38.46%)显著高于对照组(53.85%,17.31%)(P<0.01)。[结论]三维适形放射治疗可用于非小细胞肺癌的综合治疗,其毒副反应轻,有较好的近期疗效。

The Value of Three Dimensional Conformal Radiation Therapy in Multi-modality Therapy for Non-small Cell Lung Cancer

[Purpose]To evaluate the value of three dimensional conformal radiation therapy(3DCRT)in multi-modality therapy for patients with non-small cell lung cancer(NSCLC).[Methods]Fifty-two cases underwent conventional radiotherapy with dose of 36Gy/18fraction in 3.6 weeks through anterioposterior/posterioanterior fields,followed by 3DCRT with dose of 30~42Gy/10~14fraction.Fifty-two cases as control group received conventional radiotherapy with dose of 60~62Gy/30~31fraction.The patients in the 2 groups all received chemotherapy following radiotherapy.[Results]The occurrence of acute radiation esophagitis and acute radiation pneumonitis in the study group were less significantly than those in control group(P<0.05,P<0.01).The response rate(CR PR)in the study group was higher significantly than that in control group(P<0.05).1-and 2-year local control rates in the study group(78.8%,51.9%)were higher significantly than in those control group(46.2%,15.4%)respectively(P<0.01).1-and 2-year survival rates in the study group(63.46%,38.46%)were superiorer significantly than those in control group(53.85%,17.31%)respectively(P<0.01).[Conclusions] 3DCRT may apply to multi-modality therapy for treatment of NSCLC with short term response rate and mild toxicity.