当归和硝苯吡啶合用对慢性阻塞性肺疾病伴肺动脉高压近期疗效观察

将40例慢性阻塞性肺疾病伴肺动脉高压缓解期患者随机分成4组,即当归组,硝苯吡啶组,当归和硝苯吡啶联用组和空白组,每组10例,7天为1个疗程。对比观察各组患者用药前后血流动力学、肺功能和动脉血气变化。结果表明,联合用药组患者平均肺动脉压降低(P<0.01),心排血量增加(P<0.01),动脉血氧分压升高(P<0.05),而且疗效明显优于单用一种药和不用药组,克服了硝苯吡啶对患者动脉血氧分压的不良影响。

Observation on Short-term Effects of Angelica Sinensis and Nifedipine on COPD Patients with Pulmonary Hypertension

40 COPD cases with pulmonary hypertension(PH) in remission stage were equally divided into four groups, 10 cases in each. Group 1-4 were treated with 25% Angelica sinensis (250 ml, iv. drip,qd), nifedipine(10mg, po, tid), both Agelica sinensis nifedipine and blank control respectively. Thestudy was designed to. investigate the changes of hemodynamics, pulmonary function and blood gasbefore and after the treatments by impedance. rheopneumogram, lung function examination andblood gas analysis. Results: Mean pulmonary arterial pressure was decreased and cardiac output,PaO_2 were increased significantly(P<0.05 or P<0.01) in group 3. The effects of group 3 appearedto be better than in other groups. The side effect of PaO_2 lowering in group 2 was overcome in addingAngelica sinensis.