重组链激酶对犬冠状动脉栓塞的作用

本研究用２６只犬，分成５组分别为：生理盐水（ＮＳ）对照组、重组链激酶（ｒ－ＳＫ）１５０００ＩＵ／ｋｇ组、ｒ－ＳＫ３００００ＵＩ／ｋｇ组、ｒ－ＳＫ６００００ＵＩ／ｋｇ组及阳性对照链激酶（ＳＫ）３００００ＵＩ／ｋｇ组，以观察ｒ－ＳＫ的溶栓作用。在犬冠状动脉左前降支分支插管导入血栓后，心电图ＳＴ段抬高，心率明显减慢，冠状动脉造影见冠状动脉断流。用ｒ－ＳＫ后，栓塞引起的ＳＴ段抬高缓解，但心率无明显变化。冠状动脉造影的结果表明，随着ｒ－ＳＫ的剂量升高栓塞溶解的犬数增加。血液生化指标显示ｒ－ＳＫ对凝血时间和凝血酶原时间无影响，延长优球蛋白溶解时间，但降低纤溶酶原含量，增加Ｄ二聚体的含量。与ＮＳ组比较，ｒ－ＳＫ组心肌梗死面积明显减小。本研究证明静脉注射ｒ－ＳＫ能溶解犬冠状动脉栓塞。

Effects of recombinant streptokinase on coronary thrombotic occlusion in canine

The effects of different doses of recombinant streptokinase (r SK) on canine coronary thrombotic occulsion were studied. Twenty six dogs were divided into five groups: the negative controlnormal saline solution (NS) group, r SK 15 000UI/kg group, r SK 30 000UI/kg group, r SK 60 000UI/kg group, and positive control SK 3 000 UI/kg group. After inducing thrombi (human plasma fibrinogen thrombase after coagulating for an hour) into a diagonal branch of the left anterior descended on the coronary angiogram. In r SK treated groups the elevated ST segment restored but heart rate did not change significangly. The coronary angiograms showed that r SK dissolved the voronary thrombi. The number of the canine with thrombolysis increased with the doses of r SK. The r SK did not influence clot time and prothrombin time, but prolonged the euglobulin clot lysis time, decreased plasminogen content in blood plasma and increased the D dimer of the fibrin degradation product. The myocardial infarct area was significantly smaller in r SK group than that in NS group. The results of this study proved that recombinant streptokinase given intravenously can dissolve the coronary thrombi.