Comparison of ready-to-use EMDOGAIN®-gel and EMDOGAIN® in patients with chronic adult periodontitis |
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| Authors: | G. Bratthall,P. Lindberg,A. Havemose-Poulsen,P. Holmstrup,L. Bay,G. Sö derholm,O. Norderyd,B. Andersson,B. Rickardsson,H. Hallströ m,B. Kullendorff, H. Skö ld Bell |
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| Affiliation: | 1. Department of Periodontology, Malm?;2. University, Sweden;3. Department of Periodontology, Copenhagen University, Denmark;4. STP Periodontology, Malm?;5. STP Periodontology, Lund;6. STP Periodontology, Ystad;7. STP Periodontology, Halmstad;8. Department of Oral Radiology, Malm? University;9. Private Clinic, Malm?, Sweden |
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| Abstract: | OBJECTIVES: The aim of this multicenter trial was to compare the clinical and radiographical outcome of a ready-to-use Emdogain-gel (test) with the marketed Emdogain (control). METHODS: Subjects with bilateral infrabony defects > or =4 mm deep and > or =2 mm wide according to radiographs were selected. 88 subjects with probing pocket depth (PPD) > or =6 mm > or =1 month after supervised oral hygiene and scaling participated. At baseline plaque index, bleeding on probing, PPD and probing attachment level were recorded and reproducible radiographs for computer-based bone level measurements were taken. In each subject, 1 tooth was randomly treated with the test and 1 tooth with the control gel. Examinations were repeated 8 and 16 months post-operatively. RESULTS: After 16 months, the mean test PPD was 4.1 mm and the mean control PPD 4.2 mm. The mean gain of attachment was 2.7 mm for test and 2.9 mm for the control sites, and the radiographic measurements demonstrated a mean gain of 1 mm for both test and control sites. CONCLUSION: This series of cases demonstrated a statistically significant reduction of pocket depths and gain of attachment and bone after 8 and 16 months with no difference between the 2 preparations. |
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| Keywords: | infrabony defect regeneration enamel matrix proteins radiographs |
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