| 兔血浆中5-单硝酸异山梨醇酯及药动学参数的毛细管气相色谱-电子捕获检测法测定 |
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| 引用本文： | 蒋文蕾,夏桂珠. 兔血浆中5-单硝酸异山梨醇酯及药动学参数的毛细管气相色谱-电子捕获检测法测定[J]. 中国医药工业杂志, 2002, 33(7): 344-345 |
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| 作者姓名： | 蒋文蕾 夏桂珠 |
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| 作者单位： | 北京大学药学院,北京,100083 |
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| 摘 要： | 采用毛细管气相色谱－电子捕获检测法测定兔血浆中的5－单硝酸异山梨醇酯及其在兔体内的获物动力学参数。结果显示血浆药物浓度在50－1500ng/ml范围内线性关系良好，通过回收率试验确定了方法的准确度。
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| 关 键 词： | 血浆 5－单硝酸异山梨醇酯 药动学 参数 毛细管气相色谱－电子捕获检测法 测定 |
| 文章编号： | 1001-8255(2002)07-0344-02 |
| 修稿时间： | 2001-12-07 |
Determination of Isosorbide-5-mononitrate in Rabbit Plasma and Its Pharmacokinetic Parameters by CGC-ECD |
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| JIANG Wen Lei,XIA Gui Zhu. Determination of Isosorbide-5-mononitrate in Rabbit Plasma and Its Pharmacokinetic Parameters by CGC-ECD[J]. , 2002, 33(7): 344-345 |
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| Authors: | JIANG Wen Lei XIA Gui Zhu |
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| Affiliation: | JIANG Wen Lei,XIA Gui Zhu * |
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| Abstract: | A capillary GC ECD method for the determination of isosorbide 5 mononitrate in rabbit plasma was established. The accuracy of the method was checked by recoveries. The calibration curve was linear in the range of 50~1500 ng/ml( r =0.9984). The pharmacokinetic study was also reported. |
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| Keywords: | isosorbide 5 mononitrate capillary GC ECD pharmacokinetic determination |
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