含氟酪蛋白磷酸肽-磷酸钙复合物对牙齿耐磨性的影响

目的研究含氟酪蛋白磷酸肽-磷酸钙复合物(CPP-ACP)在体外对酸蚀牛牙釉质耐磨性的影响。方法选择新鲜拔除的牛下切牙40个,每个牙冠唇面形成5mm×5mm的釉质窗,其余部分由抗酸指甲油涂抹封闭,将釉质块样本完全随机分为4组,每组10个,A组为阴性对照组;B组使用20%磷酸溶液酸蚀;C组经酸蚀后使用CPP-ACP再矿化处理;D组则经酸蚀后使用含氟CPP-ACP再矿化。每组分别采取以上不同处理方式后进入磨损循环,每个循环磨损3600次,共4个循环,总计磨损次数14400次。使用三维白光干涉表面形貌仪,测定每个样本磨损深度,比较各组磨损量的差别。结果 D组磨损量小于C组,C组及D组磨损量均低于A组和B组,各组间的差异具有统计学意义(P<0.01)。结论含氟酪蛋白磷酸肽-磷酸钙复合物可以提高酸蚀牙釉质的耐磨性。

Effect of casein phosphopeptide-amorphous calcium phosphate with fluoride on the erosive tooth wear in an in vitro model

Objective To investigate the effect of casein phosphopeptide-amorphous calcium phosphate（CPP-ACP） with fluoride on the erosive enamel wear.Methods Forty bovine lower incisors were collected,and 5mm×5mm enamel window on each crown created.The other areas were sealed with nail polisher.The samples were stratified and allocated into 4 groups（A-D）with 10 samples in each group,which were then treated with different method.Group A remained untreated and served as negative control.Group B and C were treated by phosphoric acid,group C was further renimeralized with CPP-ACP,group D was renimeralized by CPP-ACP with fluoride after the erosion.After the above treatment,the samples received tooth wear,which included 4 circulations,with 3600 strokes in each circulation,14400 strokes in total.The quantity of enamel wear was recorded.Results The quantity of enamel wear in group D was significantly lower than in group C,group D and group C were lower than group A and B.There was significant difference between each group（P〈0.01）.Conclusion Casein phosphopeptide-amorphous calcium phosphate with fluoride can reduce tooth wear.