The role of specific and non-specific interactions in receptor-mediated endocytosis of nanoparticles |
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Authors: | Decuzzi P Ferrari M |
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Affiliation: | BioNEM-Center of Bio-/Nanotechnology and -/Engineering for Medicine, University of Magna Graecia, Viale Europa - Loc. Germaneto 88100 Catanzaro, Italy. p.decuzzi@poliba.it |
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Abstract: | The role of specific and non-specific interactions in the receptor-mediated endocytosis of nanoparticles is analyzed. The characteristic time tau(w), the threshold R(th) and optimal R(opt) radii for particle endocytosis are estimated as a function of the binding energy factor C, bond elasticity factor G, and non-specific attractive/repulsive factor F at the cell-particle interface. It is shown that the contribution of F is as important as that of C and G. General and ready to use formulas are presented that can be a guide in designing nanoparticles with controlled endocytic performances. |
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