乳腺癌血管内皮生长因子表达的预后意义

目的　探讨乳腺浸润性导管癌中血管内皮生长因子 (VEGF)的表达与患者预后的关系。方法　采用免疫组化 L SAB法观察 70例乳腺浸润性导管癌组织中 VEGF的表达 ,并结合随访资料评价 VEGF表达水平对预测乳癌患者预后的价值。结果　生存率分析显示 ,VEGF表达增强组无复发生存期及治后生存期均短。Kaplan- Meirer生存曲线显示 ,VEGF高表达组复发率高 ,死亡率高 ,预后差。多元回归分析证实 ,VEGF具有重要的预后预测价值 ,但不能作为独立的预后指标。结论　 VEGF表达水平可作为判断乳癌患者预后的指标之一。

The Prognostic Value of Vascular Endothelial Growth Factor in Breast Cancer

Objective To define the relevance of VEGF status to the prognosis of breast cancer. Methods The tissues of 70 invasive ductal breast carcinomas were evaluated for VEGF protein expression by immunohistochemistry LSAB method, and the prognostic value of VEGF status was assessed in combination with the follow up data on those breast cancer patients. Results VEGF status was inversely correlated with relapse free survival and overall survival . Kaplan Merier survival curve showed that VEGF rich tumor group had higher relapse rate and mortality rate. Multivariate regression analysis confirmed that the VEGF status had certain prognostic value, but it could not be considered as an independent prognostic indicator. Conclusion VEGF status is one of the significant prognostic indicators of breast cancer.