Reduced Foxp3 expression with increased cytomegalovirus-specific CTL in HTLV-I-associated myelopathy |
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Authors: | Hayashi Daisuke Kubota Ryuji Takenouchi Norihiro Tanaka Yuetsu Hirano Ryuki Takashima Hiroshi Osame Mitsuhiro Izumo Shuji Arimura Kimiyoshi |
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Institution: | Department of Neurology and Geriatrics, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima 890-8544, Japan. |
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Abstract: | Human T-lymphotropic virus type I (HTLV-I)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients show high immune responses to HTLV-I. However, it is unclear whether the cytotoxic T lymphocyte (CTL) responses to other chronic viruses also increase. We investigated the responses in the peripheral blood by using HLA-A*0201/peptide pentamers. The frequency of cytomegalovirus (CMV)-specific CTL tended to be higher in HAM/TSP patients than in healthy controls (HCs). The frequency of CMV-specific CTL positively correlated with that of HTLV-I Tax-specific CTL. The frequency of Foxp3+ cells in CD4+ lymphocytes tended to be higher in HAM/TSP patients than in ACs and HCs. The expression level of Foxp3 was lower in HAM/TSP patients than in HCs and was inversely correlated with the CMV-specific CTL frequency. A percentage of Foxp3+ cells showed a positive correlation with the HTLV-I proviral load. These results suggest that a decrease in the Foxp3 expression may contribute to the high immune response to CMV and that the Foxp3+ regulatory T cells may play a role in the immune surveillance of HTLV-I. |
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Keywords: | HAM/TSP HTLV-I CMV CTL Foxp3 Viral load |
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