| 环氧化酶-2对鼻咽癌血管生成及预后的影响 |
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| 引用本文： | 许新华,胡国清,李松,薛峰,李道俊,戴德兰,陈燕.环氧化酶-2对鼻咽癌血管生成及预后的影响[J].中德临床肿瘤学杂志,2006,5(2):104-107. |
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| 作者姓名： | 许新华 胡国清 李松 薛峰 李道俊 戴德兰 陈燕 |
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| 作者单位： | [1]The First College of Clinical Medical Science, China Three Gorges University, Yichang 443003, China [2]Department of Oncology, Yichang Central People＇s Hospital, Yichang 443003, China [3]Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China |
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| 摘 要： | Objective： The purpose of this study was to evaluate cyclooxygenase-2 （COX-2） expression in nasopharyngeal carcinoma （NPC） and its correlation with clinicopathologic features, angiogenesis, and prognosis. Methods： The expressions of COX-2 and vascular endothelial growth factor （VEGF） and microvascular density （MVD） were determined with immunohistochemical methods in eighty-six NPC patients followed up over 5 years. Results： Sixty-three tumors （73.3%） were classified as COX-2 positive. COX-2 expression was positively related to VEGF expression （r=0.438, P〈0.01） and correlated with the tumor pathological grade, extent of primary lesion, lymph node metastasis, distant metastasis and shorter survival. Conclusion： Our results suggest that COX-2, being highly expressed and strongly correlated with angiogenesis in nasopharyngeal carcinoma, is apt to be used as a predictor of prognosis, including local recurrence and distant metastasis.
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| 关 键 词： | 鼻咽肿瘤 环氧化酶-2 血管生成 免疫组织化学 预后 |
| 收稿时间： | 2005-09-28 |
| 修稿时间： | 2005-11-15 |
Expression of Cyclooxygenase-2 in Nasopharyngeal Carcinoma
and Its Relation to Angiogenesis and Prognosis |
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| Xinhua XU,Guoqing HU,Song LI,Feng XUE,Daojun LI,Delan DAI,Yan CHEN.Expression of Cyclooxygenase-2 in Nasopharyngeal Carcinoma
and Its Relation to Angiogenesis and Prognosis[J].The Chinese-German Journal of Clinical Oncology,2006,5(2):104-107. |
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| Authors: | Xinhua XU Guoqing HU Song LI Feng XUE Daojun LI Delan DAI Yan CHEN |
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| Institution: | (1) The First College of Clinical Medical Science, China Three Gorges University, 443003 Yichang, China;(2) Department of Oncology, Yichang Central People's Hospital, 443003 Yichang, China;(3) Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430030 Wuhan, China |
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| Abstract: | Objective: The purpose of this study was to evaluate cyclooxygenase-2 (COX-2) expression in nasopharyngeal carcinoma (NPC) and its correlation with clinicopathologic features, angiogenesis, and prognosis. Methods: The expressions of COX-2 and vascular endothelial growth factor (VEGF) and microvascular density (MVD) were determined with immunohistochemical methods in eighty-six NPC patients followed up over 5 years. Results: Sixty-three tumors (73.3%) were classified as COX-2 positive. COX-2 expression was positively related to VEGF expression (r=0.438, P<0.01) and correlated with the tumor pathological grade, extent of primary lesion, lymph node metastasis, distant metastasis and shorter survival. Conclusion: Our results suggest that COX-2, being highly expressed and strongly correlated with angiogenesis in nasopharyngeal carcinoma, is apt to be used as a predictor of prognosis, including local recurrence and distant metastasis. |
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| Keywords: | nasopharyngeal neoplasms Cyclooxygenase-2 angiogenesis immunohistochemistry prognosis |
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