Central nervous system and cardiac manifestations of hydrochlorothiazide overdosage; treatment with hemodialysis |
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Authors: | M Zahid F A Krumlovsky D Roxe F del Greco M Mistovich |
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Affiliation: | Department of Medicine, Northwestern University Medical School, Chicago, IL. |
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Abstract: | A patient with end-stage renal failure inadvertently received high-dose hydrochlorothiazide as treatment for hypertension, resulting in CNS and cardiac toxicity. These toxic manifestations were successfully treated with hemodialysis. A hydrochlorothiazide dialysance of 62.5 mL/min was demonstrated. The possibility of hydrochlorothiazide toxicity should be considered in any patient with renal insufficiency who exhibits unexplained arrhythmias or symptoms related to the CNS. |
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