| 有机硼化合物的药理活性及构效关系研究进展 |
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| 引用本文： | 王震宇,周伟澄.有机硼化合物的药理活性及构效关系研究进展[J].药学进展,2009,33(6):241-246. |
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| 作者姓名： | 王震宇 周伟澄 |
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| 作者单位： | 上海医药工业研究院创新药物与制药工艺国家重点实验室,上海,200437 |
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| 基金项目： | 上海市科学技术委员会科研计划 |
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| 摘 要： | 综述具有药理活性的有机硼化合物及其构效关系的研究进展，包括硼酸类抗肿瘤化合物、含硼杂环类及硼烷类抗感染化合物、硼酸类凝血酶抑制剂以及硼酸类二肽基肽酶抑制剂等。并重点介绍了已上市抗肿瘤药物硼替佐米的药理作用机制、合成方法、药效及临床研究。
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| 关 键 词： | 有机硼化合物 硼替佐米 药理活性 构效关系 |
Progress of Studies on Pharmacological Activity and Structure-activity Relationship of Organic Boron Compounds |
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| WANG Zhen-yu,ZHOU Wei-cheng.Progress of Studies on Pharmacological Activity and Structure-activity Relationship of Organic Boron Compounds[J].Progress in Pharmaceutical Sciences,2009,33(6):241-246. |
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| Authors: | WANG Zhen-yu ZHOU Wei-cheng |
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| Institution: | (State Key Lab of New Drug ＆ Pharmaceutical Process, Shanghai Institute of Pharmaceutical Industry, Shanghai 200437, China) |
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| Abstract: | The recent progress of studies on bioactive organic boron compounds, including anti-tumor agents, antibacterial agents, thrombin inhibitors and dipeptidyl peptidase IV inhibitors, and their structure-activity relationship was reviewed. The mechanism, synthesis, pharmacodynamics and clinic trial of the launched anti-tumor drug bortezomib were emphatically introduced. |
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| Keywords: | organic boron compound bortezomib pharmacological activity structure-activity relationship |
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