早期骨肉瘤患者动脉介入治疗疗效观察

目的 探讨早期骨肉瘤患者行动脉介入治疗后的临床疗效.方法 对38例早期骨肉瘤患者行动脉栓塞化疗及手术治疗,36例(94.7%)患者行保肢手术;同时治疗前后分别行碱性磷酸酶测定.结果 手术后所有患者碱性磷酸酶水平[平均(191.7±107.0)u/L)]较介入治疗前[平均(1129.1±572.3)U/L)]明显降低(t=10.290,P＜0.01).随访12～60个月,1、3、5年生存率分别为97%、79%、50%;肿瘤复发及转移率为24%.结论 对早期骨肉瘤患者行动脉栓塞联合化疗治疗可有效改善临床症状,提高生存率,减轻复发和转移,保留患肢;碘油作为栓塞材料效果最明显.

Observation of therapeutic effects in arterial interventional therapy in early osteosarcoma patients

Objective To explore the clinical therapeutic effects in arterial interventional therapy in early osteosarcoma patients.Methods Thirty-eight early osteosarcoma patients received arterial chemoembolization therapies and performed operations.94.7% patients received limb salvage surgeries.Levels of alkaline phosphatase were tested in preoperative and postoperative phases.Results Levels of postoperativealkaline phosphatase[average(191.7±107.0)U/L]were significantly decreased compared with that before interventional therapy[average(1129.1±572.3)U/J.The survival rate in follow-up at 1,3 and 5 years Was97%,79%,50% respectively.The rate of recurrence and metastasis WAg 24%.Conclusions Arterialchemoembolization therapies in patients with early osteosarcoma could improve clinical symptoms effectively,enhance survival rate,relieve recurrence and metastasis,remain affected extremity.The clinical thempeutic effects of iodinated oil were the best among the three embolism materials.