75例发热性输液反应分析

目的分析发热性输液反应（FRI）的发生原因及相关影响因素。方法采用回顾性研究方法统计分析某三甲医院75例FRI患者的年龄、性别、原发疾病、细菌内毒素试验（BET）结果、发生季节分布和药物配伍情况。结果75例发热性输液反应中90．7％的患者所输液体BET为阴性；FRI发生特点为女性略高于男性，5～8月为多发季节，体质弱的患者发生率较高，呈逐年下降的趋势；发生率与配伍药物相关。生物生化及酶类、中草药注射液类、青霉素及头孢菌素类分别占配伍药物的17．2％，15．3％，7．4％。结论75例FRI主要是药物热，服从药品不良反应的一般规律。

Analysis of Feverish Reaction of Infusion in 75 Inpatients

Objective To analyse the causes and relevant influence factors of feverish reaction of infusion （FRI）. Methods The total of 75 inpatients with FRI in the hospital were retrospectively analyzed in terms of sex, age, former disease, results of bacterial endotoxic test （BET）, distribution of seasons and compatibility of medicines. Results The negative rate of BET was 90.7% in 75 cases. FRI in the female was more than that in the male. FRI occurred more often in the weak physique and seasons from May to August and decreased year after year. The incidence rate of FRI was related to the co-used medicines, 17.2% for biochemical and enzymic medicines,5.3% for Chinese traditional medicinal injections, 7.4% for cephalosporins and penicillins. Conclusion FRI in 75 cases was mainly medicinal fever and accorded with the general law of adverse drug reactions （ADRs）.