肾移植127例康复5年应用CsA临床观察

肾移植８０１例，人、肾５年存活率７４．６４％、５３．０２％。对其中１２７例长期应用ＣｓＡ康复５年以上的肾移植受者作了临床研究并保持定期随访。研究表明：应改善病人术前全身状况，提高组织配型和取肾质量。慢性排斥是影响移植肾长期存活的主要因素，早期确诊、一周内及时调整免疫抑制剂用量是提高逆转率的关键。应重视肺部感染和ＣｓＡ肝毒性的防治，ＣｓＡ序贯性用药疗效可靠，定期随访是提高长期康复率的保证

OBSERVATION OF CsA IN THE MANAGEMENT OF RENAL TRANSPLANTATION LONG-TERM SURVIVING

CsA in the management of 127 cases of renal transplantation surviving over 5 years between Apr, 1977 and Dec, 1994 was studied.The results indicated that we should inprove general condition of the patient before operation and increase quality of tissue-typing and operation. Chronic rejection was a primary factor affecting long-term survival .Early diagnosis and adjustment of immunosuppression drug in a week incresed revesing rate. Paying attention to pulmonary infection and CsA hepatotoxicity was emphasized. Sequencial use of CsA was effective. The periodic follow-up was the guarantee to increase surviving rate.