| 血清饥饿条件下p21活化激酶6(PAK6)与雄激素受体表达的相关性及其意义 |
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| 引用本文： | 刘彤,李丹妮,李洋,李丰.血清饥饿条件下p21活化激酶6(PAK6)与雄激素受体表达的相关性及其意义[J].解剖学研究,2013(2):81-84. |
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| 作者姓名： | 刘彤 李丹妮 李洋 李丰 |
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| 作者单位： | 中国医科大学基础医学院细胞生物教研室/教育部医学细胞生物学重点实验室;中国医科大学 |
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| 基金项目： | 国家自然科学基金资(31171360) |
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| 摘 要： | 目的血清饥饿条件诱导前列腺癌细胞系中内源性p21活化激酶6(PAK6)与雄激素受体(AR)蛋白表达,探讨PAK6与AR蛋白表达的关系。方法在前列腺癌细胞系CWR22Rv1和LNcap细胞进行血清饥饿,诱导内源性PAK6与AR蛋白表达发生变化。结果血清饥饿处理的不同时间点,CWR22Rv1和LNCaP细胞中PAK6蛋白表达呈上升趋势,AR蛋白表达呈下降趋势。瞬时转染递增剂量的PAK6引起AR蛋白表达的抑制。结论血清饥饿条件诱导前列腺癌细胞中PAK6与AR蛋白表达呈负相关。1
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| 关 键 词： | p21活化激酶 雄激素受体 血清饥饿 前列腺癌细胞 |
The relationship of p21 activated kinase 6 (PAK6) and androgen receptor upon serum starvation |
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| LIU Tong,LI Dan-ni,LI Yang,LI Feng.The relationship of p21 activated kinase 6 (PAK6) and androgen receptor upon serum starvation[J].Anatomy Research,2013(2):81-84. |
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| Authors: | LIU Tong LI Dan-ni LI Yang LI Feng |
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| Institution: | .The Research Center for Cell Biology,Key Laboratory of Medical Cell Biology Ministry of Public Education of China,China Medical University,Shenyang 110001,China |
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| Abstract: | Objective To learn the expression relationship of p21-activated kinase 6(PAK6)and androgen receptor(AR) in prostate cell line upon serum starvation.Methods Serum was abolished from medium in CWR22Rv1 and LNCaP cells,and the expression level of PAK6 and AR was examined.Results At the different time point of serum starvation,PAK6 was downregulated and AR was upregulated.Transient transfection with dose-increasing PAK6 induced downregulation of AR protein.Conclusion The expression of PAK6 and AR showed a negative correlation upon serum starvation in prostate cell lines. |
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| Keywords: | p21-activated kinase 6(PAK6) Androgen receptor Serum starvation Prostate cell line |
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