匹罗卡品癫痫模型中蛋白质netrin-1的表达与苔藓纤维出芽的动态变化 |
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引用本文: | 郑佳丽,杨金升,石向群,马亚杰,刘学娟. 匹罗卡品癫痫模型中蛋白质netrin-1的表达与苔藓纤维出芽的动态变化[J]. 临床神经电生理学杂志, 2011, 0(3): 129-131 |
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作者姓名: | 郑佳丽 杨金升 石向群 马亚杰 刘学娟 |
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作者单位: | 兰州军区兰州总医院神经内科,甘肃兰州730050 |
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摘 要: | 目的:探讨神经诱向因子蛋白质netrin-1在癫痫持续状态后海马苔藓纤维出芽(MFS)中的作用。方法:氯化锂-匹罗卡品建立大鼠颞叶癫痫(TLE)模型,采用Timm染色和免疫组化的方法分别检测MFS和netrin-1在大鼠海马组织中的表达。结果:TLE组大鼠在模型形成的第2周和第4周,海马齿状回内netrin-1的表达较正常对照组明显增加,并可见到MFS,穿越齿状回颗粒细胞层到达内分子层,并形成一条致密的层状带。结论:癫痫状态后在海马齿状回netrin-1的表达上调,证明其可能参与了癫痫后MFS过程。
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关 键 词: | 蛋白质netrin-1 颞叶癫痫(TLE) 苔藓纤维出芽(MFS) |
The expression of netrin-1 and the process of mossy fiber sprouting after pilocarpine-induced epilepsy model in rats |
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Affiliation: | ZHENG Jiali, YANG Jinsheng, SHI Xiangqun, et al (Dept of Neurology ,Lanzhou General Hospital of PLA, Lanzhou (730050) ,Gansu China) |
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Abstract: | Objective:To explore the correlation between axon guiding cues netrin-1 and the process of aberrant mossy fiber sprouting (MFS) following status epilepticus(SE)in rats. Methods:The temporal lobe epilepsy(TLE)animal model was established by lithium-pilocarpine in rats. The process of aberrant MFS and the expression of netrin-1 was observed with Timm and immunohistochemical staining. Results: In the 2nd and 4th weeks after seizure,netrin-1 immunostaining showed an increase of netrin-1 in the dentate gyrus and MFS was found after TLE. Conclusion:The netrin-1 may be involved in the process of MFS. |
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Keywords: | Netrin-1 Temporal lobe epilepsy(TLE) Mossy fiber spmuting(MFS) |
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