喉鳞状细胞癌中Snail mRNA表达及临床意义

目的 探讨Snail mRNA在人喉鳞状细胞癌(简称喉癌)组织中的表达及与临床病理特征的关系,并探讨它在喉癌发生、发展中的作用及其临床应用价值.方法 应用原位分子杂交方法检测Snail mRNA在60例喉癌、30例喉不典型增生和20例喉慢性炎症组织中的表达.结果 60例喉癌组织中Snail mRNA的阳性表达率为70%...

Expression and clinical significance of Snail mRNA in laryngeal squamous carcinoma

OBJECTIVE To investigate the relationship between the expression of Snail mRNA in tissue of laryngeal squamous carcinoma and clinico-pathological features of this disease,to explore its roles in the carcinogenesis and progression of laryngeal squamous carcinoma and its clinicopathologic significance.METHODS The expression of Snail mRNA was detected by using in situ hybridization（ISH）.All the patients included 60 cases of laryngeal squamous carcinoma,30 cases of laryngeal atypical hyperplasia and 20 cases of chronic inflammation of the larynx.RESULTS The positive rate of Snail mRNA in laryngeal tissues of 60 patients with laryngeal squamous carcinoma was（70%,42/60）,which was higher than that of patients with laryngeal atypical hyperplasia（20%,6/30）and that of patients with chronic inflammation of the larynx（5%,1/20）.All the differences were significant（χ2=18.131,P0.01;χ2=22.946,P0.01）.The expression of Snail mRNA was relevant to thyroid cartilage involvement,lymph node metastasis,distant metastasis,pathologic stage and TNM stage（P all0.05）,nevertheless irrelevant to gender and age（P all0.05）.CONCLUSION The high expression of Snail mRNA in laryngeal mucosa might be an important biological marker of canceration of laryngeal mucosa,which may be important to predict the infiltration and metastasis of laryngeal squamous carcinoma.